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    slc30a5 solute carrier family 30 member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 436594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc30a5provided by ZNC
    Official Full Name
    solute carrier family 30 member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-6
    See related
    Ensembl:ENSDARG00000051921 AllianceGenome:ZFIN:ZDB-GENE-040718-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92436; wu:fi03d07
    Summary
    Predicted to enable zinc:proton antiporter activity. Acts upstream of or within response to zinc ion. Predicted to be located in Golgi apparatus; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Orthologous to human SLC30A5 (solute carrier family 30 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc30a5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (54716669..54729536, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (54093833..54106700, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene pro-melanin-concentrating hormone, like Neighboring gene cyclin B1 Neighboring gene uncharacterized LOC137495524 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression. Wagatsuma T, et al. J Biol Chem, 2022 Jun. PMID 35525268, Free PMC Article
    2. Localized Infections with P. aeruginosa Strains Defective in Zinc Uptake Reveal That Zebrafish Embryos Recapitulate Nutritional Immunity Responses of Higher Eukaryotes. Secli V, et al. Int J Mol Sci, 2023 Jan 4. PMID 36674459, Free PMC Article
    3. Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster. Zheng D, et al. Physiol Genomics, 2008 Jul 15. PMID 18477665, Free PMC Article
    4. Life-cycle exposure to cadmium induced compensatory responses towards oxidative stress in the liver of female zebrafish. Zhu QL, et al. Chemosphere, 2018 Nov. PMID 30208555
    5. The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas. Kong N, et al. Gene, 2020 Aug 5. PMID 32423892

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression.
      Title: Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular zinc ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to zinc ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import into Golgi lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion import into Golgi lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in zinc ion import into organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within zinc ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proton-coupled zinc antiporter SLC30A5
    Names
    ZnT5
    solute carrier family 30 (zinc transporter), member 5
    zinc transporter 5
    znT-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002322.1 → NP_001002322.1  proton-coupled zinc antiporter SLC30A5

      See identical proteins and their annotated locations for NP_001002322.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076517
      UniProtKB/Swiss-Prot
      Q6DG36
      Related
      ENSDARP00000068124.2, ENSDART00000073634.3
      Conserved Domains (2) summary
      COG1230
      Location:411 → 739
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:424 → 659
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      54716669..54729536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DG36.1 GenPept UniProtKB/Swiss-Prot:Q6DG36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.