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    crfb1 cytokine receptor family member b1 [ Danio rerio (zebrafish) ]

    Gene ID: 569454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crfb1provided by ZNC
    Official Full Name
    cytokine receptor family member b1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8673
    See related
    Ensembl:ENSDARG00000068681 AllianceGenome:ZFIN:ZDB-GENE-030131-8673
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa94a03; wu:fa94a03; zgc:165377
    Summary
    Enables interferon receptor activity. Acts upstream of or within cytokine-mediated signaling pathway and defense response to virus. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crfb1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (19095030..19122890)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (19087318..19111894)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108191306 Neighboring gene charged multivesicular body protein 2Ba Neighboring gene cytokine receptor family member b2 Neighboring gene POU class 1 homeobox 1 Neighboring gene si:ch211-277p15.1 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1Fa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Super resolution microscopy reveals that caveolin-1 is required for spatial organization of CRFB1 and subsequent antiviral signaling in zebrafish. Gabor KA, et al. PLoS One, 2013. PMID 23874753, Free PMC Article
    2. Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals. Sun B, et al. Dev Comp Immunol, 2014 Dec. PMID 25149134
    3. Distinct antiviral activities of IFNφ1 and IFNφ4 in zebrafish. Chen K, et al. Fish Shellfish Immunol, 2024 Mar. PMID 38244820
    4. The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. Aggad D, et al. J Immunol, 2009 Sep 15. PMID 19717522
    5. Identification of type I IFNs and their receptors in a cyprinid fish, the topmouth culter Culter alburnus. Li B, et al. Fish Shellfish Immunol, 2020 Jul. PMID 32387477

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. zCRFB1 and zCRFB5 were identified as the two subunits of the zebrafish IFN receptor.
      Title: Identification of the zebrafish IFN receptor: implications for the origin of the vertebrate IFN system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC165377

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interferon receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to virus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within immune response-activating signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytokine receptor family member b1
    Names
    ifnar2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079681.1 → NP_001073149.1  cytokine receptor family member b1

      See identical proteins and their annotated locations for NP_001073149.1

      Status: PROVISIONAL

      Source sequence(s)
      EF014952
      UniProtKB/TrEMBL
      A0A2R8QBQ4, A0FJH7, B3DJR4
      Related
      ENSDARP00000090199.3, ENSDART00000099426.5
      Conserved Domains (2) summary
      pfam01108
      Location:20 → 104
      Tissue_fac; Tissue factor
      pfam09294
      Location:115 → 217
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      19095030..19122890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478750.2 → XP_021334425.1  cytokine receptor family member b1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QJT3
      Related
      ENSDARP00000119243.2, ENSDART00000137087.3
      Conserved Domains (1) summary
      cl21522
      Location:46 → 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394747.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      239391..263936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395277.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      74575..99120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001099233.1: Suppressed sequence

      Description
      NM_001099233.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.