cxxc1b CXXC finger protein 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cxxc1bprovided by ZNC
Official Full Name: CXXC finger protein 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030728-4
See related: Ensembl:ENSDARG00000025718 AllianceGenome:ZFIN:ZDB-GENE-030728-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: LWS-2; cxxc1; opn1lw2; zgc:55527
Summary: Predicted to enable methylated histone binding activity. Acts upstream of or within blood vessel development; epigenetic regulation of gene expression; and hemopoiesis. Predicted to be located in nucleus. Predicted to be part of Set1C/COMPASS complex. Is expressed in eye; long double cone cell; retinal cone cell; and retinal photoreceptor layer. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (25539745..25550845)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (25302129..25313229)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that LWS-activating region (LAR) regulates both LWS-1 and LWS-2 by enhancing their expression and that interaction of LAR with the promoters is competitive between the two genes in a developmentally restricted manner.
Title: A single enhancer regulating the differential expression of duplicated red-sensitive opsin genes in zebrafish.
CFP1 has an important role during postgastrulation development
Title: Antisense targeting of CXXC finger protein 1 inhibits genomic cytosine methylation and primitive hematopoiesis in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CXXC-type zinc finger protein 1b

Names: CXXC finger 1 (PHD domain); CXXC finger protein 1; cfp1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200333.1 → NP_956627.1 CXXC-type zinc finger protein 1b

See identical proteins and their annotated locations for NP_956627.1

Status: PROVISIONAL

Source sequence(s)

BC052918

UniProtKB/TrEMBL

Q7SZE4

Related

ENSDARP00000032784.6, ENSDART00000035602.7

Conserved Domains (3) summary

pfam02008
Location:115 → 162

zf-CXXC; CXXC zinc finger domain

cd15553
Location:27 → 72

PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)

pfam12269
Location:309 → 543

zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain