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    psmb6 proteasome 20S subunit beta 6 [ Danio rerio (zebrafish) ]

    Gene ID: 30388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psmb6provided by ZNC
    Official Full Name
    proteasome 20S subunit beta 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-216
    See related
    Ensembl:ENSDARG00000002240 AllianceGenome:ZFIN:ZDB-GENE-990415-216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    y; beta1; zgc:109823
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within immune system process and proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB6 (proteasome 20S subunit beta 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See psmb6 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (44537442..44546081, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (44720922..44729561, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:ch73-375g18.1 Neighboring gene platelet glycoprotein Ib alpha chain Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene mucin-4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sequencing of amphioxus PSMB5/8 gene and phylogenetic position of agnathan sequences. Takezaki N, et al. Gene, 2002 Jan 9. PMID 11814690
    2. Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP). Nourizadeh-Lillabadi R, et al. J Toxicol Environ Health A, 2009. PMID 19184727
    3. Purification and Identification of the 20S Proteasome Complex from Zebrafish. Hasan AM, et al. Zebrafish, 2022 Feb. PMID 35171713
    4. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. McConnell SC, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27493218, Free PMC Article
    5. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proteasome subunit beta type-6
    Names
    proteasome (prosome, macropain) subunit, beta type, 6
    proteasome subunit Y
    proteasome subunit beta 6
    NP_571227.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131152.1 → NP_571227.1  proteasome subunit beta type-6

      See identical proteins and their annotated locations for NP_571227.1

      Status: PROVISIONAL

      Source sequence(s)
      AF032392
      UniProtKB/TrEMBL
      O57332
      Related
      ENSDARP00000025226.5, ENSDART00000024082.7
      Conserved Domains (2) summary
      TIGR03690
      Location:23 → 209
      20S_bact_beta; proteasome, beta subunit, bacterial type
      cd03762
      Location:24 → 210
      proteasome_beta_type_6; proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      44537442..44546081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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