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    ypel3 yippee-like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 368214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ypel3provided by ZNC
    Official Full Name
    yippee-like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030516-4
    See related
    Ensembl:ENSDARG00000055510 AllianceGenome:ZFIN:ZDB-GENE-030516-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ypel1; cb475; wu:fi27c07
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within brain development; filopodium assembly; and glial cell differentiation. Predicted to be located in nucleolus. Is expressed in several structures, including central nervous system; pronephric duct; tail bud; ventral mesoderm; and yolk syncytial layer. Orthologous to human YPEL3 (yippee like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ypel3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26186153..26191637, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26055282..26060766, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene si:ch211-11k18.4 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3a Neighboring gene mitogen-activated protein kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development. Blanco-Sánchez B, et al. PLoS Genet, 2020 Jun. PMID 32544203, Free PMC Article
    2. Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Li C, et al. Gene, 2024 Apr 5. PMID 38242380
    3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
    4. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon JM, et al. Hum Mol Genet, 2017 Oct 1. PMID 28934389, Free PMC Article
    5. Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Lu X, et al. Cell Discov, 2015. PMID 27462426, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development.
      Title: yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein yippee-like 3
    Names
    proteim yippee-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212790.1 → NP_997955.1  protein yippee-like 3

      See identical proteins and their annotated locations for NP_997955.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067578
      UniProtKB/Swiss-Prot
      Q6NWI4
      Related
      ENSDARP00000099958.3, ENSDART00000113843.5
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      26186153..26191637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NWI4.1 GenPept UniProtKB/Swiss-Prot:Q6NWI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.