rspo1 R-spondin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rspo1provided by ZNC
Official Full Name: R-spondin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-44
See related: Ensembl:ENSDARG00000104340 AllianceGenome:ZFIN:ZDB-GENE-040718-44
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj81e05; zgc:92153; wu:fj81e05
Summary: Predicted to enable signaling receptor binding activity. Acts upstream of or within angiogenesis; hematopoietic stem cell differentiation; and vascular endothelial growth factor receptor signaling pathway. Located in Golgi apparatus and cytosol. Is expressed in several structures, including nervous system; regenerating fin; reproductive system; steroid hormone secreting cell; and tail bud. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (33773651..33818052, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (33819647..33852216, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1
Title: R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways.
hypothesized that misexpression of R-Spondin1 is necessary for AHR activation to block regeneration (R-Spondin1)
Title: Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Title: Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
These preliminary findings suggest some aspects of RSPO1 like differential expression linked to sex determination may be conserved in fish while other aspects like subcellular localization differ from the mammalian RSPO1.
Title: Molecular analysis shows differential expression of R-spondin1 in zebrafish (Danio rerio) gonads.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: R-spondin-1

Names: R-spondin homolog; cb1071; roof plate-specific spondin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002352.1 → NP_001002352.1 R-spondin-1 precursor

See identical proteins and their annotated locations for NP_001002352.1

Status: PROVISIONAL

Source sequence(s)

BC075907

UniProtKB/Swiss-Prot

Q6DHR0

UniProtKB/TrEMBL

M5AP50

Related

ENSDARP00000135809.1, ENSDART00000160671.2

Conserved Domains (3) summary

smart00209
Location:149 → 208

TSP1; Thrombospondin type 1 repeats

cd00064
Location:101 → 134

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam15913
Location:44 → 145

Furin-like_2; Furin-like repeat, cysteine-rich