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    egln1b egl-9 family hypoxia-inducible factor 1b [ Danio rerio (zebrafish) ]

    Gene ID: 436868, updated on 4-Jan-2025

    Summary

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    Official Symbol
    egln1bprovided by ZNC
    Official Full Name
    egl-9 family hypoxia-inducible factor 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-338
    See related
    Ensembl:ENSDARG00000004632 AllianceGenome:ZFIN:ZDB-GENE-040718-338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    egln1; fk45e02; zgc:92314; wu:fk45e02
    Summary
    Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and regulation of neuron apoptotic process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See egln1b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (31558135..31603506)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (31295147..31340446)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 like 2 Neighboring gene uncharacterized LOC137496713 Neighboring gene zgc:162816 Neighboring gene hyccin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia. Dou X, et al. Life Sci, 2024 May 1. PMID 38492922
    2. Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Ma Y, et al. Front Pharmacol, 2019. PMID 31780949, Free PMC Article
    3. TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation. Fan S, et al. J Biol Chem, 2020 Nov 27. PMID 32963106, Free PMC Article
    4. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. Hyvärinen J, et al. J Biol Chem, 2010 Dec 31. PMID 20952382, Free PMC Article
    5. Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Jia PP, et al. Environ Pollut, 2023 Sep 1. PMID 37290634

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia.
      Title: Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hypoxia-inducible factor-proline dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    egl nine homolog 1b
    Names
    Hif-p4h-2
    egl nine homolog 1
    NP_001002595.2
    XP_021335268.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002595.2 → NP_001002595.2  egl nine homolog 1b

      Status: VALIDATED

      Source sequence(s)
      BC076001
      UniProtKB/TrEMBL
      A0A8M1N0S3, F6P6J7, Q6DHH3
      Related
      ENSDARP00000005048.7, ENSDART00000024296.8
      Conserved Domains (2) summary
      smart00702
      Location:152 → 326
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam01753
      Location:18 → 55
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      31558135..31603506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479593.2 → XP_021335268.1  egl nine homolog 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q756, Q6DHH3
      Conserved Domains (2) summary
      smart00702
      Location:152 → 286
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam01753
      Location:18 → 55
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version

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