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    phactr4b phosphatase and actin regulator 4b [ Danio rerio (zebrafish) ]

    Gene ID: 393643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phactr4bprovided by ZNC
    Official Full Name
    phosphatase and actin regulator 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1131
    See related
    Ensembl:ENSDARG00000032221 AllianceGenome:ZFIN:ZDB-GENE-040426-1131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    phactr4; zgc:63484
    Summary
    Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Predicted to be involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Predicted to act upstream of or within nervous system development. Predicted to be located in lamellipodium. Is expressed in Purkinje cell. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See phactr4b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (34198025..34285158, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (34243995..34331144, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene opioid receptor, delta 1b Neighboring gene regulator of chromosome condensation 1 Neighboring gene endothelin-2 Neighboring gene uncharacterized LOC137487931

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
    2. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
    3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63484

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in closure of optic fissure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in closure of optic fissure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in enteric nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in enteric nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 4B
    Names
    phosphatase and actin regulator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200670.1 → NP_956964.1  phosphatase and actin regulator 4B

      See identical proteins and their annotated locations for NP_956964.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058052
      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      Related
      ENSDARP00000044234.6, ENSDART00000044235.8
      Conserved Domains (2) summary
      smart00707
      Location:637 → 660
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 84
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      34198025..34285158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292434.4 → XP_009290709.1  phosphatase and actin regulator 4B isoform X5

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M3B1T3
      Conserved Domains (2) summary
      smart00707
      Location:693 → 716
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 84
      RPEL; RPEL repeat

    2. XM_005158334.5 → XP_005158391.1  phosphatase and actin regulator 4B isoform X3

      See identical proteins and their annotated locations for XP_005158391.1

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M3AI89
      Conserved Domains (2) summary
      smart00707
      Location:737 → 760
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 84
      RPEL; RPEL repeat

    3. XM_068213918.1 → XP_068070019.1  phosphatase and actin regulator 4B isoform X5

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M3B1T3

    4. XM_009292432.4 → XP_009290707.1  phosphatase and actin regulator 4B isoform X3

      See identical proteins and their annotated locations for XP_009290707.1

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M3AI89
      Conserved Domains (2) summary
      smart00707
      Location:737 → 760
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 84
      RPEL; RPEL repeat

    5. XM_005158335.5 → XP_005158392.1  phosphatase and actin regulator 4B isoform X4

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M2B4R2
      Conserved Domains (2) summary
      smart00707
      Location:707 → 730
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:76 → 98
      RPEL; RPEL repeat

    6. XM_005158332.5 → XP_005158389.1  phosphatase and actin regulator 4B isoform X1

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M2B587
      Conserved Domains (2) summary
      smart00707
      Location:751 → 774
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:76 → 98
      RPEL; RPEL repeat

    7. XM_005158333.5 → XP_005158390.1  phosphatase and actin regulator 4B isoform X2

      UniProtKB/Swiss-Prot
      F1QNE2, Q6PEI3
      UniProtKB/TrEMBL
      A0A8M2B574
      Conserved Domains (2) summary
      smart00707
      Location:748 → 771
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:73 → 95
      RPEL; RPEL repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEI3.2 GenPept UniProtKB/Swiss-Prot:Q6PEI3

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