eef2a.1 eukaryotic translation elongation factor 2a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eef2a.1provided by ZNC
Official Full Name: eukaryotic translation elongation factor 2a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-500
See related: Ensembl:ENSDARG00000042094 AllianceGenome:ZFIN:ZDB-GENE-050522-500
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:113191; si:dkey-110c1.3
Summary: Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (20135400..20143425)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (20110423..20118447)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: elongation factor 2a.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045161.2 → NP_001038626.2 elongation factor 2a.1

Status: PROVISIONAL

Source sequence(s)

BX005203

UniProtKB/TrEMBL

A0A8M1NA43, Q1LYG5

Related

ENSDARP00000118068.1, ENSDART00000143641.3

Conserved Domains (6) summary

cd01885
Location:20 → 233

EF2; Elongation Factor 2 (EF2) in archaea and eukarya

cd01681
Location:572 → 744

aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...

cd04096
Location:740 → 819

eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...

PTZ00416
Location:1 → 854

PTZ00416; elongation factor 2; Provisional

cd16261
Location:511 → 572

EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

cl02787
Location:392 → 486

Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins