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    Tmem116 transmembrane protein 116 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690442, updated on 27-Nov-2024

    Summary

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    Symbol
    Tmem116provided by RGD
    Full Name
    transmembrane protein 116provided by RGD
    Primary source
    RGD:1596066
    See related
    EnsemblRapid:ENSRNOG00000027480 AllianceGenome:RGD:1596066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human TMEM116 (transmembrane protein 116). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 135.8), Kidney (RPKM 76.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem116 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40681346..40750106, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35021912..35089409, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40537261..40618805, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene MAPK activated protein kinase 5 Neighboring gene ADAM metallopeptidase domain 1a Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene 40S ribosomal protein S27-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 116

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159625.1 → NP_001153097.1  transmembrane protein 116

      Status: VALIDATED

      Source sequence(s)
      BC167104
      UniProtKB/TrEMBL
      B2RZC5
      Related
      ENSRNOP00000109767.1, ENSRNOT00000154771.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40681346..40750106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271693.1 → XP_063127763.1  transmembrane protein 116 isoform X15

    2. XM_063271694.1 → XP_063127764.1  transmembrane protein 116 isoform X16

    3. XM_063271687.1 → XP_063127757.1  transmembrane protein 116 isoform X9

    4. XM_063271692.1 → XP_063127762.1  transmembrane protein 116 isoform X14

    5. XM_063271691.1 → XP_063127761.1  transmembrane protein 116 isoform X13

    6. XM_063271689.1 → XP_063127759.1  transmembrane protein 116 isoform X11

    7. XM_063271686.1 → XP_063127756.1  transmembrane protein 116 isoform X8

    8. XM_039089787.2 → XP_038945715.1  transmembrane protein 116 isoform X10

    9. XM_017598460.3 → XP_017453949.1  transmembrane protein 116 isoform X6

    10. XM_039089786.2 → XP_038945714.1  transmembrane protein 116 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRI1, B2RZC5
      Related
      ENSRNOP00000081376.1, ENSRNOT00000104465.2

    11. XM_063271685.1 → XP_063127755.1  transmembrane protein 116 isoform X7

    12. XM_063271684.1 → XP_063127754.1  transmembrane protein 116 isoform X5

    13. XM_063271683.1 → XP_063127753.1  transmembrane protein 116 isoform X3

    14. XM_006249406.5 → XP_006249468.1  transmembrane protein 116 isoform X4

      See identical proteins and their annotated locations for XP_006249468.1

      UniProtKB/TrEMBL
      A0A8I6AEQ5, A6J1E5, B2RZC5
      Related
      ENSRNOP00000092876.1, ENSRNOT00000114714.2

    15. XM_006249404.5 → XP_006249466.1  transmembrane protein 116 isoform X1

      See identical proteins and their annotated locations for XP_006249466.1

      UniProtKB/TrEMBL
      A6J1E6, B2RZC5, F1LRF5
      Related
      ENSRNOP00000063208.3, ENSRNOT00000067503.4

    16. XM_063271690.1 → XP_063127760.1  transmembrane protein 116 isoform X12

      UniProtKB/TrEMBL
      A6J1E7

    RNA

    1. XR_005491675.2 RNA Sequence

    2. XR_005491674.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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