Plxna2 plexin A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plxna2provided by RGD
Official Full Name: plexin A2provided by RGD
Primary source: RGD:1305325
See related: EnsemblRapid:ENSRNOG00000007324 AllianceGenome:RGD:1305325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and semaphorin receptor activity. Predicted to be involved in several processes, including chordate embryonic development; limb bud formation; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within cell surface receptor signaling pathway; centrosome localization; and cerebellar granule cell precursor tangential migration. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLXNA2 (plexin A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 175.4), Liver (RPKM 160.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (108683155..108888336)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (106163103..106358979)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (113373569..113570774)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-145a-5p/Plexin-A2 promotes the migration of OECs and transplantation of miR-145a-5p engineered OECs enhances the functional recovery in rats with SCI.
Title: miR-145a-5p/Plexin-A2 promotes the migration of OECs and transplantation of miR-145a-5p engineered OECs enhances the functional recovery in rats with SCI.
PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury.
Title: PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury.

Submit: New GeneRIF Correction

General gene information

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Markers

D13Got114 (e-PCR)
- UniSTS:115783

Plxna2 (e-PCR), detects polymorphism
- UniSTS:526941

AW457381 (e-PCR)
- UniSTS:178558

MARC_9713-9714:996688545:1 (e-PCR)
- UniSTS:269978

BE114222 (e-PCR)
- UniSTS:247458

D13Got103 (e-PCR)
- UniSTS:112548

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within centrosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar granule cell precursor tangential migration	ISO Inferred from Sequence Orthology more info
involved_in limb bud formation	ISO Inferred from Sequence Orthology more info
involved_in neural tube development	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105988.2 → NP_001099458.2 plexin-A2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

D3ZWP6

Related

ENSRNOP00000009900.5, ENSRNOT00000009900.9

Conserved Domains (7) summary

cd11272
Location:38 → 552

Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2

cd01179
Location:954 → 1037

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:858 → 953

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1041 → 1141

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:806 → 855

PSI; Plexin repeat

pfam01833
Location:1143 → 1227

TIG; IPT/TIG domain

pfam08337
Location:1311 → 1864

Plexin_cytopl; Plexin cytoplasmic RasGAP domain