Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmeff1provided by RGD
Official Full Name: transmembrane protein with EGF-like and two follistatin-like domains 1provided by RGD
Primary source: RGD:62005
See related: EnsemblRapid:ENSRNOG00000008034 AllianceGenome:RGD:62005
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable receptor ligand inhibitor activity. Predicted to be involved in negative regulation of viral entry into host cell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including TMEFF1 (transmembrane protein with EGF like and two follistatin like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 214.2), Lung (RPKM 94.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (67706269..67792022)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (62910740..62996494)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (64326733..64412531)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048992 (e-PCR)
- UniSTS:145440

RH144033 (e-PCR)
- UniSTS:233279

RH138909 (e-PCR)
- UniSTS:220996

D5Rat225 (e-PCR), detects polymorphism
- UniSTS:227923

BE102967 (e-PCR)
- UniSTS:244412

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand inhibitor activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tomoregulin-1

Names: TR-1; transmembrane protein with EGF-like and one follistatin-like domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429960.1 → NP_001416889.1 tomoregulin-1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5Y818, A0A8I6A3D5
NM_023020.3 → NP_075409.1 tomoregulin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_075409.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9QYV1

UniProtKB/TrEMBL

A0A8I5Y818

Related

ENSRNOP00000063443.2, ENSRNOT00000065775.4

Conserved Domains (2) summary

PHA02887
Location:268 → 304

PHA02887; EGF-like protein; Provisional

smart00280
Location:92 → 136

KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

67706269..67792022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110701.2 → XP_038966629.1 tomoregulin-1 isoform X1

Related

ENSRNOP00000103683.1, ENSRNOT00000136411.1

Conserved Domains (3) summary

PHA02887
Location:268 → 304

PHA02887; EGF-like protein; Provisional

PHA03099
Location:268 → 355

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00280
Location:92 → 136

KAZAL; Kazal type serine protease inhibitors