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    Lztr1 leucine zipper like post translational regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360745, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lztr1provided by RGD
    Official Full Name
    leucine zipper like post translational regulator 1provided by RGD
    Primary source
    RGD:1309100
    See related
    EnsemblRapid:ENSRNOG00000001870 AllianceGenome:RGD:1309100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and protein ubiquitination. Predicted to be located in Golgi apparatus and recycling endosome membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; neurilemmoma; and schwannomatosis (multiple). Orthologous to human LZTR1 (leucine zipper like post translational regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 134.2), Brain (RPKM 131.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lztr1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96991956..97008127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83487717..83503896, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87381638..87397849)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene THAP domain containing 7 Neighboring gene AIF family member 3 Neighboring gene CRK like proto-oncogene, adaptor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The integrated landscape of driver genomic alterations in glioblastoma. Frattini V, et al. Nat Genet, 2013 Oct. PMID 23917401, Free PMC Article
    2. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cancer Genome Atlas Research Network. Electronic address: [email protected], et al. Cell, 2017 Jun 15. PMID 28622513, Free PMC Article
    3. LZTR1-Related Hypertrophic Cardiomyopathy Without Typical Noonan Syndrome Features. Jenkins J, et al. Circ Genom Precis Med, 2020 Apr. PMID 32004086
    4. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis. Nacak TG, et al. J Biol Chem, 2006 Feb 24. PMID 16356934
    5. Providing more evidence on LZTR1 variants in Noonan syndrome patients. Chinton J, et al. Am J Med Genet A, 2020 Feb. PMID 31825158

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-zipper-like transcriptional regulator 1
    Names
    leucine-zipper-like transcription regulator 1
    leucine-zipper-like transcriptional regulator, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108326.2 → NP_001101796.1  leucine-zipper-like transcriptional regulator 1

      See identical proteins and their annotated locations for NP_001101796.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169071
      UniProtKB/TrEMBL
      A0A8I5Y0T3, A6JSL5, B5DFI4, F7FP96
      Related
      ENSRNOP00000082766.2, ENSRNOT00000101549.2
      Conserved Domains (6) summary
      PLN02153
      Location:65 → 347
      PLN02153; epithiospecifier protein
      sd00038
      Location:65 → 111
      Kelch; KELCH repeat [structural motif]
      cd18308
      Location:417 → 568
      BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18309
      Location:644 → 769
      BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18505
      Location:572 → 630
      BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18506
      Location:765 → 825
      BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96991956..97008127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248707.5 → XP_006248769.1  leucine-zipper-like transcriptional regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0T3
      Related
      ENSRNOP00000002554.6, ENSRNOT00000002554.8
      Conserved Domains (6) summary
      smart00225
      Location:665 → 762
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14821
      Location:571 → 631
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      sd00038
      Location:65 → 111
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:662 → 761
      BTB; BTB/POZ domain
      pfam01344
      Location:280 → 323
      Kelch_1; Kelch motif
      pfam13415
      Location:74 → 123
      Kelch_3; Galactose oxidase, central domain

    2. XM_039088534.2 → XP_038944462.1  leucine-zipper-like transcriptional regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0T3
      Conserved Domains (7) summary
      PLN02153
      Location:31 → 278
      PLN02153; epithiospecifier protein
      sd00038
      Location:46 → 95
      Kelch; KELCH repeat [structural motif]
      cd18308
      Location:291 → 442
      BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18309
      Location:518 → 643
      BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18505
      Location:446 → 504
      BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18506
      Location:639 → 674
      BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      pfam13415
      Location:1 → 54
      Kelch_3; Galactose oxidase, central domain

    3. XM_063270661.1 → XP_063126731.1  leucine-zipper-like transcriptional regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0T3
    Nucleotide Protein Strain
    Heading Accession and Version

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