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    Myef2 myelin expression factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679712, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Myef2provided by RGD
    Official Full Name
    myelin expression factor 2provided by RGD
    Primary source
    RGD:1306547
    See related
    EnsemblRapid:ENSRNOG00000005258 AllianceGenome:RGD:1306547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mRNA binding activity. Predicted to be involved in myotube differentiation; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 256.7), Thymus (RPKM 233.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myef2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (132791694..132827572, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (112338241..112374122, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117353490..117389582, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555070 Neighboring gene uncharacterized LOC134486433 Neighboring gene uncharacterized LOC108350455 Neighboring gene solute carrier family 24 member 5 Neighboring gene cortexin 2 Neighboring gene solute carrier family 12 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. McDermott JC, et al. Mol Cell Biol, 1993 Apr. PMID 8455629, Free PMC Article
    2. Identification of a sequence-specific single-stranded DNA binding protein that suppresses transcription of the mouse myelin basic protein gene. Haas S, et al. J Biol Chem, 1995 May 26. PMID 7539003
    3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109392

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myelin expression factor 2
    Names
    myelin basic protein expression factor 2, repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013205.3 → NP_001013223.2  myelin expression factor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K402, D4AEI5
      Related
      ENSRNOP00000072845.2, ENSRNOT00000081533.3
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515 → 591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      132791694..132827572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234931.4 → XP_006234993.1  myelin expression factor 2 isoform X5

      UniProtKB/TrEMBL
      D4AEI5
      Related
      ENSRNOP00000077919.2, ENSRNOT00000099942.2
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 563
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:491 → 567
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    2. XM_006234932.4 → XP_006234994.1  myelin expression factor 2 isoform X6

      UniProtKB/TrEMBL
      D4AEI5
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 546
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:474 → 550
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    3. XM_006234930.3 → XP_006234992.1  myelin expression factor 2 isoform X4

      UniProtKB/TrEMBL
      D4AEI5
      Related
      ENSRNOP00000007103.7, ENSRNOT00000007103.8
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498 → 574
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    4. XM_063284535.1 → XP_063140605.1  myelin expression factor 2 isoform X1

      UniProtKB/TrEMBL
      A6HPV5

    5. XM_063284536.1 → XP_063140606.1  myelin expression factor 2 isoform X2

      UniProtKB/TrEMBL
      A6HPV5

    6. XM_063284537.1 → XP_063140607.1  myelin expression factor 2 isoform X3

      UniProtKB/TrEMBL
      A6HPV5
    Nucleotide Protein Strain
    Heading Accession and Version

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