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    Nnat neuronatin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94270, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nnatprovided by RGD
    Official Full Name
    neuronatinprovided by RGD
    Primary source
    RGD:620155
    See related
    EnsemblRapid:ENSRNOG00000024923 AllianceGenome:RGD:620155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Peg5
    Summary
    Involved in neuron differentiation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human NNAT (neuronatin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 663.4), Adrenal (RPKM 283.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nnat in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166646373..166648845)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (146225941..146228868)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (154043873..154046334)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486197 Neighboring gene SRC proto-oncogene, non-receptor tyrosine kinase Neighboring gene uncharacterized LOC134486196 Neighboring gene BLCAP, apoptosis inducing factor Neighboring gene uncharacterized LOC108350620 Neighboring gene uncharacterized LOC120101772

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic Changes in the Localization of Neuronatin-Positive Cells during Neurogenesis in the Embryonic Rat Brain. Kanno N, et al. Cells Tissues Organs, 2019. PMID 31805566
    2. Characteristic Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas. Kanno N, et al. J Histochem Cytochem, 2019 Jul. PMID 30869556, Free PMC Article
    3. Functional characterization of the dendritically localized mRNA neuronatin in hippocampal neurons. Oyang EL, et al. PLoS One, 2011. PMID 21935485, Free PMC Article
    4. Altered neuronatin expression in the rat dorsal root ganglion after sciatic nerve transection. Chen KH, et al. J Biomed Sci, 2010 May 28. PMID 20509861, Free PMC Article
    5. Neuronatin mRNA in PC12 cells: downregulation by nerve growth factor. Joseph R, et al. Brain Res, 1996 Oct 28. PMID 8949924

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NNAT signals were broadly observed across the developing brain on embryonic day E13.5 and gradually more localized in later stages, eventually concentrated in the alar and basal parts of the terminal hypothalamus, the alar plate of prosomere 2 of the thalamus, and the choroid plexus in the lateral and fourth ventricles on embryonic day E20.5.
      Title: Dynamic Changes in the Localization of Neuronatin-Positive Cells during Neurogenesis in the Embryonic Rat Brain.
    2. Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas
      Title: Characteristic Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas.
    3. Trh, Tnxa and Nnat genes were affected according to the degree of memory in male rats.
      Title: Memory-related gene expression profile of the male rat hippocampus induced by teeth extraction and occlusal support recovery.
    4. Data propose that neuronatin may impact synaptic plasticity by modulating dendritic calcium levels during homeostatic plasticity, thereby potentially regulating neuronal excitability, receptor trafficking, and calcium dependent signaling.
      Title: Functional characterization of the dendritically localized mRNA neuronatin in hippocampal neurons.
    5. analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei
      Title: The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.
    6. significant correlation between mechanical hyperalgesia in axotomy of sciatic nerve and the increased expression of Nnat in C-fiber and A-delta fiber of adult dorsal root ganglion neurons
      Title: Altered neuronatin expression in the rat dorsal root ganglion after sciatic nerve transection.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156562

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronatin
    Names
    neuronatin alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270867.2 → NP_001257796.1  neuronatin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62649

    2. NM_001429813.1 → NP_001416742.1  neuronatin isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AR75, A6JWT7

    3. NM_001429814.1 → NP_001416743.1  neuronatin isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2QVS0

    4. NM_001429815.1 → NP_001416744.1  neuronatin isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2UKY2, A6JWT8

    5. NM_053601.3 → NP_446053.1  neuronatin isoform alpha

      See identical proteins and their annotated locations for NP_446053.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      A0JPK6, Q62649, Q62663

    6. NM_181687.3 → NP_859015.1  neuronatin isoform beta

      See identical proteins and their annotated locations for NP_859015.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62649

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166646373..166648845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284795.1 → XP_063140865.1  neuronatin isoform X1

      Related
      ENSRNOP00000034212.4, ENSRNOT00000034166.6

    2. XM_008762390.4 → XP_008760612.1  neuronatin isoform X2

      Related
      ENSRNOP00000064325.2, ENSRNOT00000072502.5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_073089.1: Suppressed sequence

      Description
      NR_073089.1: This RefSeq was removed because it is now thought that this transcript variant does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62649.1 GenPept UniProtKB/Swiss-Prot:Q62649

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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