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    Mtch Mitochondrial carrier homolog 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtchprovided by FlyBase
    Official Full Name
    Mitochondrial carrier homolog 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027786
    Locus tag
    Dmel_CG6851
    See related
    AllianceGenome:FB:FBgn0027786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6851; Dmel\CG6851
    Summary
    Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Used to study dilated cardiomyopathy. Orthologous to human MTCH1 (mitochondrial carrier 1) and MTCH2 (mitochondrial carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtch in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (184626..186310)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (184626..186310)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Vitamin D[[3]] up-regulated protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MAP kinase-specific phosphatase Neighboring gene rhinoceros Neighboring gene mrityu Neighboring gene Glycerol kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development. González C, et al. FEBS Open Bio, 2024 Feb. PMID 38013241, Free PMC Article
    2. Opposing effects of genetic variation in MTCH2 for obesity versus heart failure. Fischer JA, et al. Hum Mol Genet, 2023 Jan 1. PMID 35904451, Free PMC Article
    3. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï M, et al. J Neurobiol, 2003 Dec. PMID 14608664
    4. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246, Free PMC Article
    5. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development.
      Title: Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial carrier homolog 1
    Names
    CG6851-PA
    CG6851-PB
    CG6851-PC
    CG6851-PE
    CG6851-PF
    CG6851-PG
    Mtch-PA
    Mtch-PB
    Mtch-PC
    Mtch-PE
    Mtch-PF
    Mtch-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      184626..186310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259597.2 → NP_001246526.1  mitochondrial carrier homolog 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Y4
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 222
      Mito_carr; Mitochondrial carrier protein

    2. NM_167799.3 → NP_728481.1  mitochondrial carrier homolog 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Y4
      Related
      FBpp0072379
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 222
      Mito_carr; Mitochondrial carrier protein

    3. NM_001259598.2 → NP_001246527.1  mitochondrial carrier homolog 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Y4
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 222
      Mito_carr; Mitochondrial carrier protein

    4. NM_167800.3 → NP_728482.1  mitochondrial carrier homolog 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Y4
      Related
      FBpp0072381
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 222
      Mito_carr; Mitochondrial carrier protein

    5. NM_001259596.2 → NP_001246525.1  mitochondrial carrier homolog 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Y4
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 222
      Mito_carr; Mitochondrial carrier protein

    6. NM_079145.4 → NP_523869.1  mitochondrial carrier homolog 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3Y4
      Related
      FBpp0072380
      Conserved Domains (1) summary
      pfam00153
      Location:142 → 222
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3Y4 Q9V3Y4

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