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    CG12268 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42833, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG12268provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039131
    Locus tag
    Dmel_CG12268
    See related
    AllianceGenome:FB:FBgn0039131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12268
    Summary
    Predicted to enable alcohol-forming long-chain fatty acyl-CoA reductase activity and alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; embryonic Malpighian tubule tip cell; embryonic hypopharynx; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12268 in Genome Data Viewer
    Location:
    95D1-95D1; 3-82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23943628..23948424, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19769350..19774146, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S19b Neighboring gene uncharacterized protein Neighboring gene Glutamate dehydrogenase Neighboring gene Glutamyl-prolyl-tRNA synthetase Neighboring gene antisense RNA:CR46092 Neighboring gene Adaptor Protein complex 1, sigma subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila. Finet C, et al. Genome Biol Evol, 2019 Jun 1. PMID 31076758, Free PMC Article
    2. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article
    3. Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity. Ghosh AC, et al. Elife, 2020 Oct 27. PMID 33107824, Free PMC Article
    4. A genomic analysis of Drosophila somatic sexual differentiation and its regulation. Arbeitman MN, et al. Development, 2004 May. PMID 15056610
    5. An inventory of peroxisomal proteins and pathways in Drosophila melanogaster. Faust JE, et al. Traffic, 2012 Oct. PMID 22758915, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12268-PA
    CG12268-PB
    CG12268-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23943628..23948424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176550.2 → NP_788727.1  uncharacterized protein Dmel_CG12268, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCF6
      Related
      FBpp0083901
      Conserved Domains (3) summary
      cd09071
      Location:372 → 463
      FAR_C; C-terminal domain of fatty acyl CoA reductases
      cd05236
      Location:22 → 347
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:12 → 463
      PLN02996; fatty acyl-CoA reductase

    2. NM_142940.3 → NP_651197.1  uncharacterized protein Dmel_CG12268, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCF6
      Related
      FBpp0083900
      Conserved Domains (3) summary
      cd09071
      Location:372 → 463
      FAR_C; C-terminal domain of fatty acyl CoA reductases
      cd05236
      Location:22 → 347
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:12 → 463
      PLN02996; fatty acyl-CoA reductase

    3. NM_001260343.1 → NP_001247272.1  uncharacterized protein Dmel_CG12268, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247272.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCF6
      Conserved Domains (3) summary
      cd09071
      Location:372 → 463
      FAR_C; C-terminal domain of fatty acyl CoA reductases
      cd05236
      Location:22 → 347
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:12 → 463
      PLN02996; fatty acyl-CoA reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCF6 Q9VCF6

    Gene LinkOut

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