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    Ca-beta Ca2+-channel-protein-beta-subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34557, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ca-betaprovided by FlyBase
    Official Full Name
    Ca2+-channel-protein-beta-subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287724
    Locus tag
    Dmel_CG42403
    See related
    AllianceGenome:FB:FBgn0287724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2L5; ca-beta; CaBeta; CG14922; CG14923; CG33305; CG42403; CG6320; DmCa1beta; dmcab1; Dmel\CG42403; l(2)04008
    Old locus tag
    Dmel_CG33305; Dmel_CG6320
    Summary
    Enables voltage-gated calcium channel activity. Involved in calcium ion transmembrane transport; calcium-mediated signaling; and neuron remodeling. Predicted to be part of voltage-gated calcium channel complex. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Ca-beta in Genome Data Viewer
    Location:
    32D5-32E1; 2-44 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11156118..11203544, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11156118..11203544, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 32E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vitelline membrane 32E Neighboring gene Buddy of Hmr 2 Neighboring gene long non-coding RNA:CR43859 Neighboring gene abrupt Neighboring gene CENP-meta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca(2+) channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity. Medeiros AT, et al. Elife, 2024 Sep 18. PMID 39291956, Free PMC Article
    2. Biochemical evidence accumulates across neurons to drive a network-level eruption. Thornquist SC, et al. Mol Cell, 2021 Feb 18. PMID 33453167, Free PMC Article
    3. Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior. Leinwand SG, et al. Neuron, 2021 Jun 2. PMID 33915110, Free PMC Article
    4. Spontaneous Ca(2+) Influx in Drosophila Pupal Neurons Is Modulated by IP(3)-Receptor Function and Influences Maturation of the Flight Circuit. Chakraborty S, et al. Front Mol Neurosci, 2017. PMID 28473752, Free PMC Article
    5. Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila. Trombley S, et al. Nat Commun, 2023 Oct 14. PMID 37838791, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ca2+-channel-protein-beta-subunit
    Names
    CG42403-PE
    CG42403-PG
    CG42403-PJ
    CG42403-PL
    CG42403-PM
    CG42403-PN
    CG42403-PO
    CG42403-PP
    CG42403-PQ
    Ca-beta-PE
    Ca-beta-PG
    Ca-beta-PJ
    Ca-beta-PL
    Ca-beta-PM
    Ca-beta-PN
    Ca-beta-PO
    Ca-beta-PP
    Ca-beta-PQ
    Ca2+-channel-protein beta subunit
    Ca[2+]-channel-protein-beta-subunit
    calcium channel beta
    calcium channel beta subunit
    lethal (2) 04008

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11156118..11203544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259049.3 → NP_001245978.1  Ca2+-channel-protein-beta-subunit, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEF5
      Conserved Domains (4) summary
      cd11863
      Location:69 → 130
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:211 → 392
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:25 → 65
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:221 → 393
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_001273447.1 → NP_001260376.1  Ca2+-channel-protein-beta-subunit, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCW6
      Conserved Domains (2) summary
      pfam00625
      Location:72 → 253
      Guanylate_kin; Guanylate kinase
      cl17190
      Location:82 → 254
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. NM_001298907.1 → NP_001285836.1  Ca2+-channel-protein-beta-subunit, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDV0
      Conserved Domains (4) summary
      cd11863
      Location:69 → 130
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:207 → 388
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:25 → 65
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:217 → 389
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. NM_205962.3 → NP_995684.2  Ca2+-channel-protein-beta-subunit, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTE7
      Conserved Domains (4) summary
      cd11863
      Location:69 → 130
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:207 → 388
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:25 → 65
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:217 → 389
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    5. NM_001259050.3 → NP_001245979.2  Ca2+-channel-protein-beta-subunit, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND67
      Conserved Domains (3) summary
      cd11863
      Location:85 → 146
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:223 → 404
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:41 → 81
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    6. NM_078822.4 → NP_523546.1  Ca2+-channel-protein-beta-subunit, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U0D3, Q9VKI5
      Related
      FBpp0289763
      Conserved Domains (4) summary
      cd11863
      Location:69 → 130
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:207 → 388
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:25 → 65
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:217 → 389
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    7. NM_001273448.2 → NP_001260377.1  Ca2+-channel-protein-beta-subunit, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFL4
      Conserved Domains (4) summary
      cd11863
      Location:85 → 146
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:230 → 411
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:41 → 81
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:240 → 412
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    8. NM_205963.4 → NP_995685.3  Ca2+-channel-protein-beta-subunit, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTE8
      Conserved Domains (4) summary
      cd11863
      Location:85 → 146
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:234 → 415
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:41 → 81
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:244 → 416
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    9. NM_001273446.1 → NP_001260375.1  Ca2+-channel-protein-beta-subunit, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD84
      Conserved Domains (4) summary
      cd11863
      Location:85 → 146
      SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta
      pfam00625
      Location:234 → 415
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:41 → 81
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:244 → 416
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND67 M9ND67
    M9NEF5 M9NEF5
    M9PCW6 M9PCW6
    M9PD84 M9PD84
    M9PFL4 M9PFL4
    Q7KTE7 Q7KTE7
    Q7KTE8 Q7KTE8
    Q8T0P1 Q8T0P1
    Q9VKI5 Q9VKI5
    X2JDV0 X2JDV0

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