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    Eip63F-1 Ecdysone-induced protein 63F 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eip63F-1provided by FlyBase
    Official Full Name
    Ecdysone-induced protein 63F 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004910
    Locus tag
    Dmel_CG15855
    See related
    AllianceGenome:FB:FBgn0004910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    63F-1; Ca[2+] binding protein; CBP12; CG15855; Dmel\CG15855; E63-1; E63F; Eip63-1; eip63F-1; Eip63F1; Eip63Fa
    Summary
    Enables calcium ion binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut; embryonic/larval salivary gland; ganglia; and imaginal disc. Orthologous to human CALML5 (calmodulin like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eip63F-1 in Genome Data Viewer
    Location:
    63F6-64A1; 3-9 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3909973..3935617, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3909973..3935617, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene imaginal discs arrested Neighboring gene maggie Neighboring gene antisense RNA:Ecdysone-induced gene 63F 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila 63F early puff contains E63-1, an ecdysone-inducible gene that encodes a novel Ca(2+)-binding protein. Andres AJ, et al. Development, 1995 Aug. PMID 7671827
    2. Ecdysone signaling cascade and regulation of Drosophila metamorphosis. Baehrecke EH. Arch Insect Biochem Physiol, 1996. PMID 8913033
    3. Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Bender M, et al. Cell, 1997 Dec 12. PMID 9413987
    4. Glue secretion in the Drosophila salivary gland: a model for steroid-regulated exocytosis. Biyasheva A, et al. Dev Biol, 2001 Mar 1. PMID 11180965
    5. Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila. van der Graaf K, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561245, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ecdysone-induced protein 63F 1
    Names
    CG15855-PA
    CG15855-PB
    CG15855-PC
    CG15855-PD
    Eip63F-1-PA
    Eip63F-1-PB
    Eip63F-1-PC
    Eip63F-1-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3909973..3935617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202116.1 → NP_001189045.1  Ecdysone-induced protein 63F 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSK2
      Conserved Domains (1) summary
      PTZ00184
      Location:11 → 161
      PTZ00184; calmodulin; Provisional

    2. NM_001202118.2 → NP_001189047.1  Ecdysone-induced protein 63F 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS04
      Conserved Domains (1) summary
      PTZ00184
      Location:9 → 166
      PTZ00184; calmodulin; Provisional

    3. NM_001202117.2 → NP_001189046.1  Ecdysone-induced protein 63F 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRP5
      Conserved Domains (1) summary
      PTZ00184
      Location:21 → 181
      PTZ00184; calmodulin; Provisional

    4. NM_080163.4 → NP_524902.2  Ecdysone-induced protein 63F 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524902.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48593, Q9I7T4, Q9VZL0
      UniProtKB/TrEMBL
      C6SUU8
      Related
      FBpp0073031
      Conserved Domains (1) summary
      PTZ00184
      Location:33 → 193
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRP5 M9MRP5
    M9MS04 M9MS04
    M9MSK2 M9MSK2
    P48593.2 P48593
    Q95TC2 Q95TC2

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