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    adcyap1a adenylate cyclase activating polypeptide 1a [ Danio rerio (zebrafish) ]

    Gene ID: 259257, updated on 15-Dec-2024

    Summary

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    Official Symbol
    adcyap1aprovided by ZNC
    Official Full Name
    adenylate cyclase activating polypeptide 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020809-4
    See related
    Ensembl:ENSDARG00000004015 AllianceGenome:ZFIN:ZDB-GENE-020809-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    PACAP1; adcyap1; GHRH-LP1; GRF-PACAP; zgc:103760; ghrh-pacap1; xx:af217251
    Summary
    Predicted to enable neuropeptide hormone activity; peptide hormone receptor binding activity; and pituitary adenylate cyclase activating polypeptide activity. Acts upstream of or within brain development and camera-type eye development. Predicted to be located in extracellular region. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including central nervous system; germ ring; gut; head; and male organism. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See adcyap1a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71547747..71556731)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71306606..71315590)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene alkaline ceramidase 2 Neighboring gene thymidylate synthetase Neighboring gene methyltransferase 4, N6-adenosine Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene structural maintenance of chromosomes flexible hinge domain-containing protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae. Holmberg A, et al. J Exp Biol, 2004 Nov. PMID 15498954
    2. Pituitary adenylate cyclase-activating polypeptide in the brain, spinal cord and sensory organs of the zebrafish, Danio rerio, during development. Mathieu M, et al. Brain Res Dev Brain Res, 2004 Jul 19. PMID 15246703
    3. Characterization of the gene encoding both growth hormone-releasing hormone (GRF) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish. Fradinger EA, et al. Mol Cell Endocrinol, 2000 Jul 25. PMID 10940499
    4. Distribution of pituitary adenylate cyclase-activating polypeptide 2 in zebrafish brain. Nakamachi T, et al. Peptides, 2018 May. PMID 29535004
    5. Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish. Krueckl SL, et al. J Comp Neurol, 2003 Jan 13. PMID 12483690

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study reveals the distribution of immunoreactive GHRH-like peptide in structures of the zebrafish brain; results suggest involvement of GHRH-LP in both neuroendocrine and feeding-associated nervous circuits
      Title: Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio).
    2. expression of transcripts for PACAP and its receptors by 0.5-6 hpf make both PACAP1 and PACAP2 candidates for factors that influence brain development
      Title: Role of two genes encoding PACAP in early brain development in zebrafish.
    3. The temporal and spatial expression pattern of the ghrh-pacap1 transcript suggests that thise hormones may modulate patterning during development.
      Title: Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish.
    4. signal pathways, transcript distribution, and splice variants are investigated
      Title: Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase activating polypeptide 1a
    Names
    growth hormone-releasing hormone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328496.1 → NP_001315425.1  adenylate cyclase activating polypeptide 1a isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      FP016237
      UniProtKB/TrEMBL
      B5DDL8, F6P3I8, Q5XJ29
      Related
      ENSDARP00000008265.6, ENSDART00000012070.8
      Conserved Domains (1) summary
      pfam00123
      Location:81 → 107
      Hormone_2; Peptide hormone

    2. NM_152885.2 → NP_690841.1  adenylate cyclase activating polypeptide 1a isoform 1 precursor

      See identical proteins and their annotated locations for NP_690841.1

      Status: VALIDATED

      Source sequence(s)
      FP016237
      UniProtKB/TrEMBL
      A0A8N7UZR9, Q9DE29
      Related
      ENSDARP00000145584.1, ENSDART00000180869.1
      Conserved Domains (1) summary
      pfam00123
      Location:81 → 107
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      71547747..71556731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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