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    cflara CASP8 and FADD-like apoptosis regulator a [ Danio rerio (zebrafish) ]

    Gene ID: 373114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cflaraprovided by ZNC
    Official Full Name
    CASP8 and FADD-like apoptosis regulator aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-3
    See related
    Ensembl:ENSDARG00000055966 AllianceGenome:ZFIN:ZDB-GENE-030826-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    FLIP; cflar; Clarp1
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cflara in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (30331809..30341431, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (30085775..30094247, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B7 Neighboring gene UDP glucuronosyltransferase 1 family, pseudogene B6 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B4 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide B1 Neighboring gene transmembrane protein 169a Neighboring gene peroxisomal trans-2-enoyl-CoA reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Inohara N, et al. Proc Natl Acad Sci U S A, 1997 Sep 30. PMID 9380701, Free PMC Article
    2. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Santoro MM, et al. Nat Genet, 2007 Nov. PMID 17934460
    3. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Sakamaki K, et al. Biochem Biophys Rep, 2015 Sep. PMID 29124180, Free PMC Article
    4. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. Rodríguez-Aznar E, et al. Cell Death Differ, 2011 Jul. PMID 21252910, Free PMC Article
    5. The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Essers PB, et al. Oncogene, 2015 Feb 5. PMID 24469044

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CASP8 and FADD-like apoptosis regulator a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313772.1 → NP_001300701.1  CASP8 and FADD-like apoptosis regulator a

      Status: VALIDATED

      Source sequence(s)
      BX323548, EH552705, EH554609, EH575723
      UniProtKB/TrEMBL
      A0A8M1P2J9, F1R706
      Related
      ENSDARP00000072840.2, ENSDART00000078378.5
      Conserved Domains (3) summary
      cd08340
      Location:100 → 180
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      pfam01335
      Location:8 → 87
      DED; Death effector domain
      cl00042
      Location:241 → 461
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      30331809..30341431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479557.2 → XP_021335232.1  CASP8 and FADD-like apoptosis regulator a isoform X1

      UniProtKB/TrEMBL
      A0A8M1P2J9, F1R706
      Conserved Domains (3) summary
      cd08340
      Location:100 → 180
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      pfam01335
      Location:8 → 87
      DED; Death effector domain
      cl00042
      Location:241 → 461
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    Nucleotide Protein Strain
    Heading Accession and Version

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