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    sp8b sp8 transcription factor b [ Danio rerio (zebrafish) ]

    Gene ID: 324931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sp8bprovided by ZNC
    Official Full Name
    sp8 transcription factor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3654
    See related
    Ensembl:ENSDARG00000056666 AllianceGenome:ZFIN:ZDB-GENE-030131-3654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Sp8; Sp8a; sp8l; fc48e06; zgc:77258; wu:fc48e06
    Summary
    Enables double-stranded DNA binding activity. Involved in embryonic limb morphogenesis. Acts upstream of or within embryonic pectoral fin morphogenesis and positive regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including apical ectodermal ridge pelvic fin bud; midbrain neural keel; nervous system; neural plate; and neural tube. Orthologous to human SP8 (Sp8 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sp8b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (19534058..19539661)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (19730779..19733846)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-233k19.3 Neighboring gene uncharacterized LOC101885538 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 5 Neighboring gene uncharacterized LOC108179597

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and cloning of two transcript isoforms of human Sp8. Milona MA, et al. BMC Genomics, 2004 Nov 8. PMID 15533246, Free PMC Article
    2. Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Penberthy WT, et al. Dev Biol, 2004 Nov 1. PMID 15464585
    3. An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra. Vogg MC, et al. Nat Commun, 2019 Jan 18. PMID 30659200, Free PMC Article
    4. Genetic basis of hindlimb loss in a naturally occurring vertebrate model. Don EK, et al. Biol Open, 2016 Feb 18. PMID 26892237, Free PMC Article
    5. Allometric growth of the trunk leads to the rostral shift of the pelvic fin in teleost fishes. Murata Y, et al. Dev Biol, 2010 Nov 1. PMID 20692249

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic pectoral fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205550.2 → NP_991113.1  transcription factor Sp8

      See identical proteins and their annotated locations for NP_991113.1

      Status: PROVISIONAL

      Source sequence(s)
      AY591904
      UniProtKB/Swiss-Prot
      Q6ED30, Q6P0J3
      UniProtKB/TrEMBL
      A0A8M9P7R9
      Related
      ENSDARP00000101509.2, ENSDART00000112894.3
      Conserved Domains (3) summary
      sd00017
      Location:302 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:357 → 379
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:343 → 366
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      19534058..19539661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466623.2 → XP_021322298.1  transcription factor Sp8 isoform X2

      UniProtKB/Swiss-Prot
      Q6ED30, Q6P0J3
      UniProtKB/TrEMBL
      A0A8M9P7R9
      Conserved Domains (3) summary
      sd00017
      Location:302 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:357 → 379
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:343 → 366
      zf-H2C2_2; Zinc-finger double domain

    2. XM_005157958.5 → XP_005158015.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_005158015.1

      UniProtKB/TrEMBL
      A0A8M2B498, Q3L0W2
      Related
      ENSDARP00000073657.5, ENSDART00000079201.6
      Conserved Domains (3) summary
      sd00017
      Location:320 → 339
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:375 → 397
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:361 → 384
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005157959.5 → XP_005158016.1  transcription factor Sp8 isoform X2

      See identical proteins and their annotated locations for XP_005158016.1

      UniProtKB/Swiss-Prot
      Q6ED30, Q6P0J3
      UniProtKB/TrEMBL
      A0A8M9P7R9
      Conserved Domains (3) summary
      sd00017
      Location:302 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:357 → 379
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:343 → 366
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0J3.1 GenPept UniProtKB/Swiss-Prot:Q6P0J3

    Gene LinkOut

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