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    mpx myeloid-specific peroxidase [ Danio rerio (zebrafish) ]

    Gene ID: 337514, updated on 15-Dec-2024

    Summary

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    Official Symbol
    mpxprovided by ZNC
    Official Full Name
    myeloid-specific peroxidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9460
    See related
    Ensembl:ENSDARG00000019521 AllianceGenome:ZFIN:ZDB-GENE-030131-9460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    drf; mpo; fj80f04; wu:fj80f04
    Summary
    Enables peroxidase activity. Acts upstream of or within inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including digestive system; hematopoietic cell; hematopoietic system; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including EPX (eosinophil peroxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mpx in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7778870..7785954, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (7787705..7827254, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene surfactant protein Ba Neighboring gene sorting nexin 24 Neighboring gene lysyl oxidase a Neighboring gene methionine adenosyltransferase 2Aa Neighboring gene phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Broad-host-range plasmids for red fluorescent protein labeling of gram-negative bacteria for use in the zebrafish model system. Singer JT, et al. Appl Environ Microbiol, 2010 Jun. PMID 20363780, Free PMC Article
    2. Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3. Lee S, et al. Sci Rep, 2024 Mar 4. PMID 38433281, Free PMC Article
    3. Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Mathias JR, et al. J Leukoc Biol, 2006 Dec. PMID 16963624
    4. Using modified whole-mount in situ hybridization to study mpo expression in zebrafish. Shen LJ, et al. Exp Ther Med, 2013 Apr. PMID 23599728, Free PMC Article
    5. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Warkentin AA, et al. Elife, 2014 Dec 22. PMID 25531068, Free PMC Article

    See all (496) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When infiltrated with Candida albicans, smu681 myeloperoxidase-deficient embryos and sibling embryos showed similar survival. Proliferation of C. albicans was more rapid in smu681 embryos than in sibling embryos, although it was eventually suppressed.
      Title: Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans.
    2. mpx expression is controlled differently in the anterior lateral plate mesoderm and posterior lateral plate mesoderm regions and describe novel roles for etv2 and gata1 during primitive neutropoiesis.
      Title: Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish.
    3. myeloperoxidase and H2O2 interact directly within neutrophils at the tissue wound
      Title: Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactoperoxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eosinophil peroxidase
    Names
    myeloperoxidase
    unm t30963
    unm_sm681
    unm_t30963
    NP_001338766.1
    NP_997944.2
    XP_021334788.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351837.1 → NP_001338766.1  eosinophil peroxidase isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CU681843
      UniProtKB/TrEMBL
      A0A8M1P4H4, Q90XS6
      Related
      ENSDARP00000043960.6, ENSDART00000043961.8
      Conserved Domains (2) summary
      pfam00386
      Location:772 → 890
      C1q; C1q domain
      cl14561
      Location:160 → 726
      An_peroxidase_like; Animal heme peroxidases and related proteins

    2. NM_212779.2 → NP_997944.2  eosinophil peroxidase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CU681843
      UniProtKB/TrEMBL
      A0A8M1PIA8, F1Q944, Q90XS6
      Related
      ENSDARP00000103509.3, ENSDART00000111058.4
      Conserved Domains (1) summary
      cl14561
      Location:160 → 726
      An_peroxidase_like; Animal heme peroxidases and related proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      7778870..7785954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479113.2 → XP_021334788.1  eosinophil peroxidase isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5S9, Q90XS6
      Conserved Domains (2) summary
      pfam00386
      Location:771 → 889
      C1q; C1q domain
      cl14561
      Location:159 → 725
      An_peroxidase_like; Animal heme peroxidases and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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