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    rcc1 regulator of chromosome condensation 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rcc1provided by ZNC
    Official Full Name
    regulator of chromosome condensation 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2216
    See related
    Ensembl:ENSDARG00000037158 AllianceGenome:ZFIN:ZDB-GENE-040426-2216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Chc1; fj77f08; zgc:65796; zgc:77114; wu:fj77f08
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of mitotic cell cycle and regulation of mitotic spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; head; immature eye; neural tube; and pectoral fin musculature. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rcc1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (34185613..34194967, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (34231579..34240946, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene opioid receptor, delta 1b Neighboring gene phosphatase and actin regulator 4b Neighboring gene endothelin-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Shen W, et al. Cell, 2022 Dec 22. PMID 36493774
    2. Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Lefkopoulos S, et al. Immunity, 2020 Nov 17. PMID 33159854
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of chromosome condensation
    Names
    chromosome condensation 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213178.1 → NP_998343.1  regulator of chromosome condensation

      See identical proteins and their annotated locations for NP_998343.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066721
      UniProtKB/TrEMBL
      Q6NY65, Q6PBB0
      Related
      ENSDARP00000054025.4, ENSDART00000054026.5
      Conserved Domains (2) summary
      COG5184
      Location:3 → 415
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:361 → 411
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      34185613..34194967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351335.3 → XP_017206824.1  regulator of chromosome condensation isoform X1

      UniProtKB/TrEMBL
      Q6NY65, Q6PBB0
      Conserved Domains (2) summary
      COG5184
      Location:3 → 415
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:361 → 411
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    Nucleotide Protein
    Heading Accession and Version

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