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    ptprsa protein tyrosine phosphatase receptor type Sa [ Danio rerio (zebrafish) ]

    Gene ID: 140820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptprsaprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase receptor type Saprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020107-3
    See related
    Ensembl:ENSDARG00000059738 AllianceGenome:ZFIN:ZDB-GENE-020107-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ptprs; RPTP[s]; RPTPsigma; zf-RPTP[s]
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within olfactory bulb development. Predicted to be located in plasma membrane. Is expressed in head and nervous system. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ptprsa in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (3384022..3680915, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (3368576..3747086, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882509 Neighboring gene thromboxane A2 receptor Neighboring gene major histocompatibility complex class I UMA Neighboring gene major histocompatibility complex class I ULA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protein tyrosine phosphatase σ regulates the synapse number of zebrafish olfactory sensory neurons. Chen X, et al. J Neurochem, 2011 Nov. PMID 21812780
    2. Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. Jiang P, et al. PLoS One, 2018. PMID 29634734, Free PMC Article
    3. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
    4. Identification of transcripts potentially involved in neural tube closure using RNA sequencing. Kindt LM, et al. Genesis, 2018 Mar. PMID 29488319, Free PMC Article
    5. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase S
    Names
    protein tyrosine phosphatase, receptor type, s, a
    receptor-type tyrosine-protein phosphatase sigma a
    XP_021325166.1
    XP_021325173.1
    XP_021325178.1
    XP_021325179.1
    XP_021325182.1
    XP_021325183.1
    XP_021325187.1
    XP_068072483.1
    XP_068072484.1
    XP_068072485.1
    XP_068072486.1
    XP_068072487.1
    XP_068072488.1
    XP_068072489.1
    XP_068072490.1
    XP_068072491.1
    XP_068072492.1
    XP_068072493.1
    XP_068072494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      3384022..3680915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469512.2 → XP_021325187.1  receptor-type tyrosine-protein phosphatase S isoform X19

      UniProtKB/TrEMBL
      A0A8M9P4K6, A0A8M9PK00
      Conserved Domains (7) summary
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:605 → 671
      FN3; Fibronectin type 3 domain
      smart00194
      Location:1229 → 1488
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:968 → 1197
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    2. XM_068216392.1 → XP_068072493.1  receptor-type tyrosine-protein phosphatase S isoform X17

      UniProtKB/TrEMBL
      A0A8M9PK00

    3. XM_021469507.2 → XP_021325182.1  receptor-type tyrosine-protein phosphatase S isoform X15

      UniProtKB/TrEMBL
      A0A8M9P4K2, A0A8M9PVR1
      Conserved Domains (7) summary
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1632 → 1891
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1371 → 1600
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:909 → 993
      fn3; Fibronectin type III domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    4. XM_021469508.2 → XP_021325183.1  receptor-type tyrosine-protein phosphatase S isoform X16

      UniProtKB/TrEMBL
      A0A8M9PEA7, A0A8M9PVR1
      Conserved Domains (7) summary
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1647 → 1906
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1386 → 1615
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:918 → 1002
      fn3; Fibronectin type III domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    5. XM_068216393.1 → XP_068072494.1  receptor-type tyrosine-protein phosphatase S isoform X18

      UniProtKB/TrEMBL
      A0A8M9PVR5

    6. XM_068216382.1 → XP_068072483.1  receptor-type tyrosine-protein phosphatase S isoform X1

      UniProtKB/TrEMBL
      A0A8M9PJX8, A0A8M9PJY3

    7. XM_021469504.2 → XP_021325179.1  receptor-type tyrosine-protein phosphatase S isoform X14

      UniProtKB/TrEMBL
      A0A8M9PJZ6, A0A8M9PS86
      Conserved Domains (7) summary
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:605 → 671
      FN3; Fibronectin type 3 domain
      smart00194
      Location:1251 → 1510
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:990 → 1219
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    8. XM_068216391.1 → XP_068072492.1  receptor-type tyrosine-protein phosphatase S isoform X12

      UniProtKB/TrEMBL
      A0A8M9PVR1
      Related
      ENSDARP00000118236.1, ENSDART00000145114.3

    9. XM_021469498.2 → XP_021325173.1  receptor-type tyrosine-protein phosphatase S isoform X7

      UniProtKB/TrEMBL
      A0A8M9PE98, A0A8M9PVP8
      Related
      ENSDARP00000077743.6, ENSDART00000083308.6
      Conserved Domains (7) summary
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1654 → 1913
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1393 → 1622
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:909 → 993
      fn3; Fibronectin type III domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    10. XM_021469491.2 → XP_021325166.1  receptor-type tyrosine-protein phosphatase S isoform X4

      UniProtKB/TrEMBL
      A0A8M9PS58, A0A8M9PS65
      Conserved Domains (7) summary
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1663 → 1922
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1402 → 1631
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:918 → 1002
      fn3; Fibronectin type III domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    11. XM_021469503.2 → XP_021325178.1  receptor-type tyrosine-protein phosphatase S isoform X13

      UniProtKB/TrEMBL
      A0A8M9PEA2, A0A8M9PS75, A0A8M9PS86
      Conserved Domains (7) summary
      cd05739
      Location:248 → 316
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:609 → 675
      FN3; Fibronectin type 3 domain
      smart00194
      Location:1255 → 1514
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:994 → 1223
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:321 → 410
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:31 → 122
      I-set; Immunoglobulin I-set domain
      cd05738
      Location:150 → 224
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    12. XM_068216390.1 → XP_068072491.1  receptor-type tyrosine-protein phosphatase S isoform X11

      UniProtKB/TrEMBL
      A0A8M9PS80

    13. XM_068216386.1 → XP_068072487.1  receptor-type tyrosine-protein phosphatase S isoform X6

      UniProtKB/TrEMBL
      A0A8M9PE90

    14. XM_068216389.1 → XP_068072490.1  receptor-type tyrosine-protein phosphatase S isoform X10

      UniProtKB/TrEMBL
      A0A8M9PS80

    15. XM_068216385.1 → XP_068072486.1  receptor-type tyrosine-protein phosphatase S isoform X5

      UniProtKB/TrEMBL
      A0A8M9P4J0

    16. XM_068216388.1 → XP_068072489.1  receptor-type tyrosine-protein phosphatase S isoform X9

      UniProtKB/TrEMBL
      A0A8M9PE92

    17. XM_068216383.1 → XP_068072484.1  receptor-type tyrosine-protein phosphatase S isoform X2

      UniProtKB/TrEMBL
      A0A8M9PJX8

    18. XM_068216387.1 → XP_068072488.1  receptor-type tyrosine-protein phosphatase S isoform X8

      UniProtKB/TrEMBL
      A0A8M9P4J3

    19. XM_068216384.1 → XP_068072485.1  receptor-type tyrosine-protein phosphatase S isoform X3

      UniProtKB/TrEMBL
      A0A8M9PJX8, A0A8M9PVP4
    Nucleotide Protein Strain
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