gap43 growth associated protein 43 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gap43provided by ZNC
Official Full Name: growth associated protein 43provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-87
See related: Ensembl:ENSDARG00000099744 AllianceGenome:ZFIN:ZDB-GENE-990415-87
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gap; cb310
Summary: Predicted to enable calmodulin binding activity and phospholipid binding activity. Acts upstream of or within axon regeneration and tissue regeneration. Predicted to be located in filopodium membrane; growth cone membrane; and synapse. Predicted to be active in cytoplasm; plasma membrane; and postsynaptic density. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (47161920..47176156)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003337230.1 (1..14231)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43.
Title: Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43.
these results and GAP43 structural features, support an involvement of the protein in the dynamic intracellular Ca2+ homeostasis, a common conserved role among the different species.
Title: Specific association of growth-associated protein 43 with calcium release units in skeletal muscles of lower vertebrates.
The results implicate the GAP43 pathway as part of an F-actin based mechanism that both stabilizes new synapses and initiates new branches near effective synapses.
Title: GAP43 phosphorylation is critical for growth and branching of retinotectal arbors in zebrafish.
elements conserved among fish, mammals, and birds within the 3.6-kb promoter
Title: Transcriptional regulatory regions of gap43 needed in developing and regenerating retinal ganglion cells.
The present data strongly suggest that phospho-GAP43 plays an active role in both the early and late stages of optic nerve regeneration in fish.
Title: Changes of phospho-growth-associated protein 43 (phospho-GAP43) in the zebrafish retina after optic nerve injury: a long-term observation.

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General gene information

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Markers

fa01e10.s1 (e-PCR)
- UniSTS:189487

GAP43 (e-PCR)
- UniSTS:205393

fa96g06 (e-PCR)
- UniSTS:204716

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon choice point recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in tissue regeneration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuromodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.