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    gpr173 G protein-coupled receptor 173 [ Danio rerio (zebrafish) ]

    Gene ID: 57926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpr173provided by ZNC
    Official Full Name
    G protein-coupled receptor 173provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000710-1
    See related
    Ensembl:ENSDARG00000042922 AllianceGenome:ZFIN:ZDB-GENE-000710-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sreb3; zgc:194661; zgc:194688
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Orthologous to human GPR173 (G protein-coupled receptor 173). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gpr173 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23410925..23426614, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23391299..23405390, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-16n15.6 Neighboring gene SUV39H1 histone lysine methyltransferase a Neighboring gene uncharacterized LOC137496345 Neighboring gene forkhead box P3b Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833454
    2. Phoenixin-20 suppresses food intake, modulates glucoregulatory enzymes, and enhances glycolysis in zebrafish. Rajeswari JJ, et al. Am J Physiol Regul Integr Comp Physiol, 2020 May 1. PMID 32208925, Free PMC Article
    3. Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish. Rajeswari JJ, et al. Sci Rep, 2020 Apr 14. PMID 32286445, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 173
    Names
    super conserved receptor expressed in brain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131498.1 → NP_571573.1  probable G-protein coupled receptor 173

      See identical proteins and their annotated locations for NP_571573.1

      Status: PROVISIONAL

      Source sequence(s)
      AB040806
      UniProtKB/Swiss-Prot
      Q9I918
      UniProtKB/TrEMBL
      B0S582
      Related
      ENSDARP00000063004.2, ENSDART00000063005.3
      Conserved Domains (1) summary
      cd15217
      Location:37 → 365
      7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23410925..23426614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167058.5 → XP_005167115.1  probable G-protein coupled receptor 173 isoform X1

      See identical proteins and their annotated locations for XP_005167115.1

      UniProtKB/Swiss-Prot
      Q9I918
      UniProtKB/TrEMBL
      B0S582
      Conserved Domains (1) summary
      cd15217
      Location:37 → 365
      7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I918.1 GenPept UniProtKB/Swiss-Prot:Q9I918

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