gata6 GATA binding protein 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gata6provided by ZNC
Official Full Name: GATA binding protein 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-000622-1
See related: Ensembl:ENSDARG00000103589 AllianceGenome:ZFIN:ZDB-GENE-000622-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb603; GATA-5
Summary: Enables DNA binding activity. Acts upstream of or within several processes, including cardioblast migration to the midline involved in heart field formation; liver development; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including blastoderm; cardiovascular system; digestive system; mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (4207160..4217877)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (4366055..4376928)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterization of GATA6 genetic variants associated with mild congenital heart defects.
Title: Functional characterization of GATA6 genetic variants associated with mild congenital heart defects.
these data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.
Title: A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.
specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT signaling and expand the number of cardiac progenitors.
Title: Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
Title: Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development.
in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.
Title: Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes.

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General gene information

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Markers

fd59g07.y1 (e-PCR)
- UniSTS:195767

fc11a01.y1 (e-PCR)
- UniSTS:192482

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardioblast migration to the midline involved in heart field formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor GATA-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326364.1 → NP_001313293.1 transcription factor GATA-6

Status: VALIDATED

Source sequence(s)

BX842700

UniProtKB/TrEMBL

A0A8N7XJJ1, Q6NW63, Q6TKR4

Related

ENSDARP00000136299.1, ENSDART00000157903.2

Conserved Domains (3) summary

smart00401
Location:346 → 395

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:350 → 401

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:112 → 285

GATA-N; GATA-type transcription activator, N-terminal
NM_131557.2 → NP_571632.2 transcription factor GATA-6

Status: VALIDATED

Source sequence(s)

BX842700

UniProtKB/TrEMBL

A0A8N7XJJ1, Q6NW63, Q6TKR4

Related

ENSDARP00000137653.1, ENSDART00000166476.2

Conserved Domains (3) summary

smart00401
Location:346 → 395

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:350 → 401

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:112 → 285

GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

4207160..4217877

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017358958.3 → XP_017214447.1 transcription factor GATA-6 isoform X2

UniProtKB/TrEMBL

A0A8M6Z1Y8

Related

ENSDARP00000129963.1, ENSDART00000167906.2
XM_017358955.2 → XP_017214444.1 transcription factor GATA-6 isoform X1

UniProtKB/TrEMBL

A0A8N7XJJ1, Q6NW63, Q6TKR4

Conserved Domains (3) summary

smart00401
Location:346 → 395

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:350 → 401

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:112 → 285

GATA-N; GATA-type transcription activator, N-terminal