anos1b anosmin 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: anos1bprovided by ZNC
Official Full Name: anosmin 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000201-13
See related: Ensembl:ENSDARG00000004932 AllianceGenome:ZFIN:ZDB-GENE-000201-13
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kal1b; kal1.2; anosmin-1b
Summary: Predicted to enable peptidase inhibitor activity. Acts upstream of or within posterior lateral line neuromast deposition. Predicted to be located in extracellular region. Predicted to be active in cell surface. Is expressed in several structures, including brain; hair cell; sensory system; tail bud; and vertical myoseptum. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (38823993..38913874)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (38837288..38927126)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our data provide a consolidated map of expression of kal 1.a and kal 1.b
Title: Localization and characterization of kal 1.a and kal 1.b in the brain of adult zebrafish (Danio rerio).
anosmin-1a encoded by kal1a and anosmin-1b,encoded by kal1b are expressed in sensory hair cells of the inner ear cristae ampullaris and the lateral line neuromasts
Title: Localization of anosmin-1a and anosmin-1b in the inner ear and neuromasts of zebrafish.

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General gene information

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Markers

kal1.2 (e-PCR)
- UniSTS:205591

fj23e11.y1 (e-PCR)
- UniSTS:198828

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within posterior lateral line neuromast deposition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anosmin-1b

Names: Kallmann syndrome 1.2 sequence; Kallmann syndrome 1b sequence

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131379.2 → NP_571454.2 anosmin-1b precursor

Status: VALIDATED

Source sequence(s)

AL953867

UniProtKB/TrEMBL

A0A8M1PBA4, F1R3Y9, Q1MT36

Related

ENSDARP00000022793.8, ENSDART00000003736.9

Conserved Domains (3) summary

smart00217
Location:113 → 159

WAP; Four-disulfide core domains

cd00063
Location:166 → 254

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:285 → 358

fn3; Fibronectin type III domain