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    crestin crestin [ Danio rerio (zebrafish) ]

    Gene ID: 30186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crestinprovided by ZNC
    Official Full Name
    crestinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000208-13
    See related
    Ensembl:ENSDARG00000105570 AllianceGenome:ZFIN:ZDB-GENE-000208-13
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Is expressed in several structures, including ectomesenchyme; embryonic structure; head; nervous system; and neural crest. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See crestin in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (47257854..47262290)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (45690506..45694942)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene transfer RNA leucine (anticodon CAG) Neighboring gene oocyte zinc finger protein XlCOF6-like Neighboring gene uncharacterized LOC137491061

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Flentke GR, et al. Alcohol Clin Exp Res, 2014 May. PMID 24512079, Free PMC Article
    2. Highly penetrant melanoma in a zebrafish model is independent of ErbB3b signaling. Santoriello C, et al. Pigment Cell Melanoma Res, 2012 Mar. PMID 22248380
    3. In situ hybridization assay-based small molecule screening in zebrafish. Jing L, et al. Curr Protoc Chem Biol, 2012 Jun 1. PMID 23001521, Free PMC Article
    4. Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis. de Soysa TY, et al. BMC Biol, 2012 May 4. PMID 22559716, Free PMC Article
    5. A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Parker HJ, et al. Nat Commun, 2019 Mar 13. PMID 30867425, Free PMC Article

    See all (184) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    crestin
    Names
    ctn

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130993.2 → NP_571068.2  crestin

      Status: VALIDATED

      Source sequence(s)
      CR450840
      UniProtKB/TrEMBL
      A0A1D5NSV4, A0A8M1PAC0
      Related
      ENSDARP00000142925.1, ENSDART00000173868.2
      Conserved Domains (1) summary
      pfam08317
      Location:38 → 201
      Spc7; Spc7 kinetochore protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      47257854..47262290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials