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    yy1a YY1 transcription factor a [ Danio rerio (zebrafish) ]

    Gene ID: 322397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    yy1aprovided by ZNC
    Official Full Name
    YY1 transcription factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1117
    See related
    Ensembl:ENSDARG00000042796 AllianceGenome:ZFIN:ZDB-GENE-030131-1117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    yy1; fb59g10; wu:fa16g07; wu:fb59g10
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of gene expression. Predicted to be located in chromatin. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in several structures, including heart; myotome; nervous system; notochord posterior region; and pronephros. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See yy1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (30857011..30863252, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (30840057..30846256, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 7 Neighboring gene tripeptidyl peptidase I Neighboring gene delta(4)-desaturase, sphingolipid 2 Neighboring gene Enah/Vasp-like a Neighboring gene EMAP like 1 Neighboring gene uncharacterized LOC137488114

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
    2. Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development. Shiu WL, et al. J Biomed Sci, 2016 Feb 29. PMID 26924789, Free PMC Article
    3. Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis. Fu CY, et al. Nucleic Acids Res, 2017 Mar 17. PMID 27913726, Free PMC Article
    4. Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging. Sasik MUT, et al. Neuroscience, 2020 Jun 1. PMID 32278060
    5. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Yue R, et al. Cell, 2009 Oct 30. PMID 19879840

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development
      Title: Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development.
    2. YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
      Title: Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
    3. Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox pathway.
      Title: Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional repressor protein YY1a
    Names
    transcription factor Yy1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212617.2 → NP_997782.1  transcriptional repressor protein YY1a

      See identical proteins and their annotated locations for NP_997782.1

      Status: VALIDATED

      Source sequence(s)
      BX546455
      UniProtKB/TrEMBL
      F6NKM3, Q6IQQ3, Q7T1S3
      Related
      ENSDARP00000062810.4, ENSDART00000062811.6
      Conserved Domains (4) summary
      COG5048
      Location:211 → 350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:270 → 290
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:268 → 290
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:283 → 308
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      30857011..30863252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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