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    zmynd11 zinc finger, MYND-type containing 11 [ Danio rerio (zebrafish) ]

    Gene ID: 553781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zmynd11provided by ZNC
    Official Full Name
    zinc finger, MYND-type containing 11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-301
    See related
    Ensembl:ENSDARG00000057249 AllianceGenome:ZFIN:ZDB-GENE-050522-301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    BS69; wu:fi38d06; zgc:110370; zgc:152745
    Summary
    Predicted to enable methylated histone binding activity. Acts upstream of or within SMAD protein signal transduction and negative regulation of BMP signaling pathway. Predicted to be active in nucleus. Is expressed in brain; gut; head; immature eye; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zmynd11 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (27224743..27256333, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (27146911..27177192, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 4B Neighboring gene disco-interacting protein 2 homolog Ca Neighboring gene uncharacterized LOC101883694 Neighboring gene vasoactive intestinal peptide receptor 2 Neighboring gene uncharacterized LOC137489251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule. Wu KM, et al. J Biomed Sci, 2006 May. PMID 16456708
    2. Newly-identified receptors for peptide histidine-isoleucine and GHRH-like peptide in zebrafish help to elucidate the mammalian secretin superfamily. Wu S, et al. J Mol Endocrinol, 2008 Nov. PMID 18757498
    3. Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish. Sun X, et al. Front Cell Dev Biol, 2018. PMID 30324105, Free PMC Article
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BRAM1 plays a biological role during zebrafish development
      Title: Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110370, MGC152745

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYND domain-containing protein 11
    Names
    Bram1
    zinc finger, MYND domain containing 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077583.3 → NP_001071051.2  zinc finger MYND domain-containing protein 11

      Status: VALIDATED

      Source sequence(s)
      BX571689
      UniProtKB/TrEMBL
      Q08CT0
      Related
      ENSDARP00000096546.4, ENSDART00000105768.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      27224743..27256333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470178.2 → XP_021325853.1  zinc finger MYND domain-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PG15, Q08CT0
      Conserved Domains (5) summary
      cd05841
      Location:272 → 353
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:158 → 258
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      cd15537
      Location:102 → 145
      PHD_BS69; PHD finger found in protein BS69
      pfam01753
      Location:582 → 617
      zf-MYND; MYND finger
      cl27055
      Location:501 → 580
      MutS_III; MutS domain III

    2. XM_021470177.2 → XP_021325852.1  zinc finger MYND domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A2R8PVB4, A0A8M9P5W8, Q08CT0
      Related
      ENSDARP00000144744.1, ENSDART00000181182.1
      Conserved Domains (5) summary
      cd05841
      Location:280 → 361
      BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
      cd05492
      Location:166 → 266
      Bromo_ZMYND11; Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene ...
      cd15537
      Location:110 → 153
      PHD_BS69; PHD finger found in protein BS69
      pfam01753
      Location:590 → 625
      zf-MYND; MYND finger
      cl27055
      Location:509 → 588
      MutS_III; MutS domain III

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395178.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      86694..118299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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