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    emc1 ER membrane protein complex subunit 1 [ Danio rerio (zebrafish) ]

    Gene ID: 565399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emc1provided by ZNC
    Official Full Name
    ER membrane protein complex subunit 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-98
    See related
    Ensembl:ENSDARG00000057255 AllianceGenome:ZFIN:ZDB-GENE-060810-98
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7158249; wu:fc76f12; si:dkey-7c22.1
    Summary
    Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of EMC complex. Human ortholog(s) of this gene implicated in cerebellar atrophy, visual impairment, and psychomotor retardation. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See emc1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (21261309..21277529)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (21334757..21350982)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2b Neighboring gene multiple EGF-like-domains 6a Neighboring gene uncharacterized LOC137489119 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene intermediate filament family orphan 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DNA Methylation of T1R1 Gene in the Vegetarian Adaptation of Grass Carp Ctenopharyngodon idella. Cai W, et al. Sci Rep, 2018 May 2. PMID 29720695, Free PMC Article
    2. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article
    3. Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. Kuretani A, et al. BMC Ecol Evol, 2021 Jul 29. PMID 34325655, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      21261309..21277529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_688678.10 → XP_693770.3  ER membrane protein complex subunit 1

      UniProtKB/TrEMBL
      A0A8M2B912, A0A8N7TE71, E9QG66
      Related
      ENSDARP00000095043.4, ENSDART00000104268.5
      Conserved Domains (2) summary
      pfam07774
      Location:758 → 963
      DUF1620; Protein of unknown function (DUF1620)
      pfam13360
      Location:27 → 239
      PQQ_2; PQQ-like domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395144.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      320216..336344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473642.2 → XP_021329317.1  ER membrane protein complex subunit 1

      UniProtKB/TrEMBL
      A0A8M9PDY1, A0A8M9Q3P5
      Conserved Domains (2) summary
      pfam07774
      Location:758 → 963
      DUF1620; Protein of unknown function (DUF1620)
      cl11493
      Location:27 → 209
      PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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