st3gal8 ST3 beta-galactoside alpha-2,3-sialyltransferase 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: st3gal8provided by ZNC
Official Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-286
See related: Ensembl:ENSDARG00000007494 AllianceGenome:ZFIN:ZDB-GENE-050417-286
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: siat4; st3gal2l; zgc:111788
Summary: Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process via lactosylceramide; protein glycosylation; and sialylation. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in membrane. Is expressed in several structures, including brain; cardiovascular system; paraxial mesoderm; pectoral fin; and pleuroperitoneal region. Orthologous to human C20orf173 (chromosome 20 open reading frame 173). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (26564541..26590419, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (26330873..26352830, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ganglioside biosynthetic process via lactosylceramide	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in sialylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ST3 beta-galactoside alpha-2,3-sialyltransferase 8

Names: ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like; alpha 2,3-sialyltransferase ST3Gal I; st3gal2-r2

NP_001004017.1

EC 2.4.3.4

XP_009304302.1

EC 2.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004017.1 → NP_001004017.1 ST3 beta-galactoside alpha-2,3-sialyltransferase 8 precursor

See identical proteins and their annotated locations for NP_001004017.1

Status: PROVISIONAL

Source sequence(s)

AJ783740

UniProtKB/TrEMBL

Q6EV32

Related

ENSDARP00000008800.6, ENSDART00000002846.8

Conserved Domains (1) summary

pfam00777
Location:89 → 341

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

26564541..26590419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306027.4 → XP_009304302.1 ST3 beta-galactoside alpha-2,3-sialyltransferase 8 isoform X1

UniProtKB/TrEMBL

A0A8M3AXN0, F1R1A7

Related

ENSDARP00000127954.1, ENSDART00000154349.3

Conserved Domains (1) summary

pfam00777
Location:89 → 341

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)