U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    itm2cb integral membrane protein 2Cb [ Danio rerio (zebrafish) ]

    Gene ID: 335863, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    itm2cbprovided by ZNC
    Official Full Name
    integral membrane protein 2Cbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7806
    See related
    Ensembl:ENSDARG00000039650 AllianceGenome:ZFIN:ZDB-GENE-030131-7806
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    itm2c; fj35c02; zgc:66349; wu:fj35c02
    Summary
    Predicted to enable amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in lysosomal membrane. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human ITM2C (integral membrane protein 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See itm2cb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (48284404..48306803, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (48430300..48444766, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 55 Neighboring gene uncharacterized LOC137488208 Neighboring gene lysophosphatidic acid receptor 5a Neighboring gene hes family bHLH transcription factor 6 Neighboring gene period circadian clock 2 Neighboring gene uncharacterized LOC110437927

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Developmental exposure to Pb(2+) induces transgenerational changes to zebrafish brain transcriptome. Meyer DN, et al. Chemosphere, 2020 Apr. PMID 31816550, Free PMC Article
    2. Embryonic atrazine exposure and later in life behavioral and brain transcriptomic, epigenetic, and pathological alterations in adult male zebrafish. Horzmann KA, et al. Cell Biol Toxicol, 2021 Jun. PMID 32737625, Free PMC Article
    3. Origin and function of activated fibroblast states during zebrafish heart regeneration. Hu B, et al. Nat Genet, 2022 Aug. PMID 35864193, Free PMC Article
    4. A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). McPartland JM, et al. Mol Genet Genomics, 2007 May. PMID 17256142
    5. foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. Crespo B, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24045113

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    integral membrane protein 2Cb
    Names
    integral membrane protein 2C

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199980.1 → NP_956274.1  integral membrane protein 2Cb

      See identical proteins and their annotated locations for NP_956274.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054689
      UniProtKB/TrEMBL
      B2GQ40, Q7SYK5
      Related
      ENSDARP00000057956.3, ENSDART00000057957.4
      Conserved Domains (1) summary
      smart01039
      Location:127 → 219
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      48284404..48306803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479096.1 → XP_021334771.1  integral membrane protein 2Cb isoform X1

      UniProtKB/TrEMBL
      A0A8M9QGD2
      Conserved Domains (1) summary
      smart01039
      Location:212 → 304
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools