rab5aa RAB5A, member RAS oncogene family, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab5aaprovided by ZNC
Official Full Name: RAB5A, member RAS oncogene family, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-139
See related: Ensembl:ENSDARG00000018602 AllianceGenome:ZFIN:ZDB-GENE-030131-139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rab5a; fj38g08; wu:fj38g08; hm:zehn1144
Summary: Predicted to enable GTPase activity. Predicted to be involved in endocytosis; intracellular protein transport; and regulation of long-term neuronal synaptic plasticity. Predicted to be located in early endosome membrane and plasma membrane. Predicted to be active in axon and postsynaptic early endosome. Is expressed in brain and trunk. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (20708498..20722192)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (21124175..21137869)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab5-mediated endocytosis of E-cadherin is enhanced at the boundary between normal and RasV12 cells.
Title: Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of long-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RAB5A, member RAS oncogene family, a

NP_958893.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201485.1 → NP_958893.1 RAB5A, member RAS oncogene family, a

See identical proteins and their annotated locations for NP_958893.1

Status: PROVISIONAL

Source sequence(s)

BC047803

UniProtKB/TrEMBL

F6P0E7, F6PD63, Q7ZUW5

Related

ENSDARP00000032505.6, ENSDART00000034124.8

Conserved Domains (2) summary

cd01860
Location:21 → 183

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

pfam00071
Location:23 → 184

Ras; Ras family