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    brap BRCA1 associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 436739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brapprovided by ZNC
    Official Full Name
    BRCA1 associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-168
    See related
    Ensembl:ENSDARG00000008560 AllianceGenome:ZFIN:ZDB-GENE-040718-168
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92894
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Ras protein signal transduction and protein ubiquitination. Predicted to be active in cytoplasm. Is expressed in lens. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See brap in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3336772..3360212)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3336468..3358903)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene zgc:56235 Neighboring gene torsin family 4, member Aa Neighboring gene N-alpha-acetyltransferase 25, NatB auxiliary subunit Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BRCA1-associated protein
    NP_001002466.1
    XP_021334829.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002466.1 → NP_001002466.1  BRCA1-associated protein

      See identical proteins and their annotated locations for NP_001002466.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076350
      UniProtKB/TrEMBL
      Q6DGJ4
      Related
      ENSDARP00000103873.3, ENSDART00000109148.4
      Conserved Domains (5) summary
      cd00162
      Location:247 → 288
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12718
      Location:144 → 227
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam01496
      Location:411 → 499
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam02148
      Location:301 → 363
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl21478
      Location:460 → 554
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      3336772..3360212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479154.2 → XP_021334829.1  BRCA1-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9QC17
      Conserved Domains (4) summary
      cd12718
      Location:143 → 226
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:300 → 362
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cd16457
      Location:245 → 288
      RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
      cl25732
      Location:381 → 542
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394799.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      65422..73250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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