churc1 churchill domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: churc1provided by ZNC
Official Full Name: churchill domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-150
See related: Ensembl:ENSDARG00000010831 AllianceGenome:ZFIN:ZDB-GENE-041001-150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101863; si:dkey-12h9.10
Summary: Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; fibroblast growth factor receptor signaling pathway involved in somitogenesis; and negative regulation of fibroblast growth factor receptor signaling pathway. Is expressed in several structures, including digestive system; ethmoid cartilage; forerunner cell group; keratinocyte; and mucus secreting cell. Orthologous to human CHURC1 (churchill domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (25929440..25934450, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (26030350..26035358, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

chch is not essential for survival, but functions to modulate early mesendodermal gene expression and limit cell migration
Title: Zebrafish churchill regulates developmental gene expression and cell migration.
Knockdown of ChCh or Sip1a results in misshapen somites that are short and narrow.
Title: Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis.
The zinc finger protein Churchill (chch) has been proposed as a regulator of cell movements and shape of the body axis of the zebrafish embryo.
Title: Expression and regulation of the zinc finger transcription factor Churchill during zebrafish development.

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General gene information

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Markers

fd06e02.x1 (e-PCR)
- UniSTS:194997

fd06e08.y1 (e-PCR)
- UniSTS:194998

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein Churchill

Names: chch

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007380.1 → NP_001007381.1 protein Churchill

See identical proteins and their annotated locations for NP_001007381.1

Status: PROVISIONAL

Source sequence(s)

BC085457

UniProtKB/Swiss-Prot

Q5SNR5, Q5U3N7

Related

ENSDARP00000022916.6, ENSDART00000005590.7

Conserved Domains (1) summary

pfam06573
Location:1 → 111

Churchill; Churchill protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

25929440..25934450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468411.2 → XP_021324086.1 protein Churchill isoform X1

UniProtKB/TrEMBL

A0A8M9PPA7

Conserved Domains (1) summary

pfam06573
Location:1 → 89

Churchill; Churchill protein