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    mxi1 max interactor 1, dimerization protein [ Danio rerio (zebrafish) ]

    Gene ID: 30485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mxi1provided by ZNC
    Official Full Name
    max interactor 1, dimerization proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-151
    See related
    Ensembl:ENSDARG00000040884 AllianceGenome:ZFIN:ZDB-GENE-990415-151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb16b12; fb55f03; wu:fb16b12; wu:fb55f03; wu:fd06a08; wu:fz74f10; etID309773.22
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including axial chorda mesoderm; median fin fold; nervous system; neural tube; and periderm. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to human MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mxi1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (30330545..30361078)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (30381368..30409337)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene stonustoxin subunit beta-like Neighboring gene adducin 3 (gamma) a Neighboring gene uncharacterized LOC137488972 Neighboring gene V-set domain-containing T-cell activation inhibitor 1-like Neighboring gene si:dkey-169i5.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of the murine Mxi1 cDNA. Shimizu E, et al. Gene, 1995 Jan 23. PMID 7835718
    2. Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. Schreiber-Agus N, et al. Oncogene, 1994 Nov. PMID 7936639
    3. Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Ruuskanen JO, et al. Mol Biol Evol, 2004 Jan. PMID 12949138
    4. Phylogenetic analysis of zebrafish basic helix-loop-helix transcription factors. Wang Y, et al. J Mol Evol, 2009 Jun. PMID 19449054
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    max-interacting protein 1
    Names
    adducin 3 (gamma)
    max interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308638.1 → NP_001295567.1  max-interacting protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon in place of the first exon of variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BX649448, EB839845, EB895068
      UniProtKB/Swiss-Prot
      P50541
      UniProtKB/TrEMBL
      A0A8M1P6J8, A3KQG1
      Related
      ENSDARP00000059922.3, ENSDART00000059923.4
      Conserved Domains (1) summary
      smart00353
      Location:61 → 113
      HLH; helix loop helix domain

    2. NM_131237.2 → NP_571312.2  max-interacting protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BX649448, EB895068
      UniProtKB/Swiss-Prot
      P50541
      UniProtKB/TrEMBL
      A0A8M1PBL3, A3KQG0
      Related
      ENSDARP00000095521.4, ENSDART00000104751.6
      Conserved Domains (1) summary
      smart00353
      Location:112 → 164
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      30330545..30361078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216253.1 → XP_068072354.1  max-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P50541
      UniProtKB/TrEMBL
      A0A8M1PBL3, A3KQG0

    2. XM_068216254.1 → XP_068072355.1  max-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      P50541
      UniProtKB/TrEMBL
      A0A8M1P6J8, A3KQG1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395120.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      36879..64848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50541.1 GenPept UniProtKB/Swiss-Prot:P50541

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