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    gtf2f2a general transcription factor IIF, polypeptide 2a [ Danio rerio (zebrafish) ]

    Gene ID: 415217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtf2f2aprovided by ZNC
    Official Full Name
    general transcription factor IIF, polypeptide 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-131
    See related
    Ensembl:ENSDARG00000069910 AllianceGenome:ZFIN:ZDB-GENE-040625-131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gtf2f2; zgc:86775; wu:fb39a05
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIF complex. Orthologous to human GTF2F2 (general transcription factor IIF subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gtf2f2a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (34695341..34706903)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (33962773..33974335)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene GPALPP motifs containing 1 Neighboring gene small nucleolar RNA SNORA31 Neighboring gene small nucleolar RNA SNORD58 Neighboring gene tumor protein, translationally-controlled 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC174761

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIF complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIF subunit 2
    Names
    general transcription factor IIF, polypeptide 2, 30kDa
    NP_001002127.2
    NP_001096603.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002127.2 → NP_001002127.2  general transcription factor IIF subunit 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CF999714, EH546307, EH556805, EH577899
      UniProtKB/TrEMBL
      A0A8M1MZY4, B8JHR3
      Related
      ENSDARP00000092894.3, ENSDART00000102118.5
      Conserved Domains (1) summary
      pfam02270
      Location:13 → 252
      TFIIF_beta; Transcription initiation factor IIF, beta subunit

    2. NM_001103133.2 → NP_001096603.1  general transcription factor IIF subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_001096603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      EH434904, EH546307, EH556805, EH577899
      UniProtKB/TrEMBL
      A0A8M1NFS0, A7MCQ3
      Related
      ENSDARP00000072210.3, ENSDART00000077744.5
      Conserved Domains (1) summary
      pfam02270
      Location:13 → 236
      TFIIF_beta; Transcription initiation factor IIF, beta subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      34695341..34706903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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