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    man2b1 mannosidase, alpha, class 2B, member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 541519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    man2b1provided by ZNC
    Official Full Name
    mannosidase, alpha, class 2B, member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-52
    See related
    Ensembl:ENSDARG00000001897 AllianceGenome:ZFIN:ZDB-GENE-050327-52
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110815
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to act upstream of or within mannose metabolic process. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See man2b1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (31258109..31276064, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (30995080..31013019, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene syntaxin 10 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b Neighboring gene tRNA methyltransferase 1 Neighboring gene si:dkey-238i5.2 Neighboring gene signal-induced proliferation-associated 1 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase
    NP_001014354.1
    XP_005169420.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014332.1 → NP_001014354.1  lysosomal alpha-mannosidase precursor

      See identical proteins and their annotated locations for NP_001014354.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091843
      UniProtKB/TrEMBL
      Q58EM3
      Related
      ENSDARP00000014955.8, ENSDART00000004780.10
      Conserved Domains (4) summary
      PLN02701
      Location:44 → 980
      PLN02701; alpha-mannosidase
      cd10810
      Location:44 → 322
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:368 → 446
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:558 → 975
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      31258109..31276064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169363.5 → XP_005169420.1  lysosomal alpha-mannosidase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BH83
      Conserved Domains (4) summary
      PLN02701
      Location:44 → 982
      PLN02701; alpha-mannosidase
      cd10810
      Location:44 → 322
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:368 → 446
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:558 → 977
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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