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    trmt1 tRNA methyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trmt1provided by ZNC
    Official Full Name
    tRNA methyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-40
    See related
    Ensembl:ENSDARG00000010978 AllianceGenome:ZFIN:ZDB-GENE-060810-40
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7150454
    Summary
    Predicted to enable metal ion binding activity; tRNA (guanine) methyltransferase activity; and tRNA binding activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be active in nucleus. Is expressed in several structures, including head; immature eye; mesoderm; midbrain; and neural plate. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See trmt1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (31236016..31258110)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (30972942..30995050)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene syntaxin 10 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b Neighboring gene si:dkey-238i5.2 Neighboring gene mannosidase, alpha, class 2B, member 1 Neighboring gene signal-induced proliferation-associated 1 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
    2. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N(2),N(2)-dimethylguanosine tRNA methyltransferase; tRNA (guanine(26)-N(2))-dimethyltransferase
    Names
    TRM1 tRNA methyltransferase 1
    tRNA methyltransferase 1 homolog
    XP_009304430.1
    XP_685886.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      31236016..31258110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_680794.9 → XP_685886.4  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8N7TED0, F1QGD9
      Related
      ENSDARP00000111075.1, ENSDART00000129393.3
      Conserved Domains (2) summary
      smart00356
      Location:639 → 663
      ZnF_C3H1; zinc finger
      pfam02005
      Location:89 → 542
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    2. XM_009306155.4 → XP_009304430.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8M3B710
      Conserved Domains (2) summary
      smart00356
      Location:596 → 620
      ZnF_C3H1; zinc finger
      pfam02005
      Location:46 → 499
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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