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    prpf4bb pre-mRNA processing factor 4Bb [ Danio rerio (zebrafish) ]

    Gene ID: 406758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prpf4bbprovided by ZNC
    Official Full Name
    pre-mRNA processing factor 4Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2799
    See related
    Ensembl:ENSDARG00000040310 AllianceGenome:ZFIN:ZDB-GENE-040426-2799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prpf4b; zgc:55623; wu:fc18e10; wu:fe47g02
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within mRNA cis splicing, via spliceosome and protein phosphorylation. Predicted to be active in nucleus. Orthologous to human PRP4K (pre-mRNA processing factor kinase PRP4K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prpf4bb in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (11473568..11505974, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (11333201..11365602, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family, member 11 Neighboring gene atypical chemokine receptor 4b Neighboring gene PX domain containing 1b Neighboring gene GLI family zinc finger 3 Neighboring gene uncharacterized LOC101884290 Neighboring gene uncharacterized LOC103909741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA processing factor 4Bb
    Names
    PRP4 pre-mRNA processing factor 4 homolog B
    PRP4 pre-mRNA processing factor 4 homolog Bb
    NP_998614.1
    XP_068073150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213449.1 → NP_998614.1  pre-mRNA processing factor 4Bb

      See identical proteins and their annotated locations for NP_998614.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048879
      UniProtKB/TrEMBL
      Q7ZUL4
      Related
      ENSDARP00000097088.2, ENSDART00000106310.5
      Conserved Domains (2) summary
      smart00220
      Location:697 → 1006
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:689 → 1006
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      11473568..11505974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217049.1 → XP_068073150.1  pre-mRNA processing factor 4Bb isoform X1

      Related
      ENSDARP00000121254.1, ENSDART00000140217.2
    Nucleotide Protein Strain
    Heading Accession and Version

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