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    sucla2 succinate-CoA ligase ADP-forming subunit beta [ Danio rerio (zebrafish) ]

    Gene ID: 406299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sucla2provided by ZNC
    Official Full Name
    succinate-CoA ligase ADP-forming subunit betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1963
    See related
    Ensembl:ENSDARG00000005359 AllianceGenome:ZFIN:ZDB-GENE-040426-1963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73397; wu:fb18c11; wu:fj38c11; wu:fj90d07
    Summary
    Predicted to enable succinate-CoA ligase (ADP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including axis; hatching gland; mesoderm; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sucla2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (10037273..10056640)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9801734..9821101)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene integral membrane protein 2Ba Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 Neighboring gene uncharacterized LOC137495924 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b Neighboring gene ATPase copper transporting beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Gut P, et al. Nat Commun, 2020 Nov 23. PMID 33230181, Free PMC Article
    2. Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Xu SS, et al. Zool Res, 2023 Jan 18. PMID 36317480, Free PMC Article
    3. Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. White RJ, et al. Elife, 2022 Feb 17. PMID 35175196, Free PMC Article
    4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
    Names
    succinate-CoA ligase, ADP-forming, beta subunit
    NP_998191.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213026.1 → NP_998191.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

      See identical proteins and their annotated locations for NP_998191.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059701
      UniProtKB/TrEMBL
      A0A8M1PIK4, Q6PBI0
      Related
      ENSDARP00000021652.7, ENSDART00000018503.9
      Conserved Domains (3) summary
      PRK00696
      Location:58 → 448
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:324 → 444
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:58 → 265
      ATP-grasp_2; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      10037273..10056640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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