bub3 BUB3 mitotic checkpoint protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bub3provided by ZNC
Official Full Name: BUB3 mitotic checkpoint proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-210
See related: Ensembl:ENSDARG00000075883 AllianceGenome:ZFIN:ZDB-GENE-041010-210
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101571
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in mitotic spindle assembly checkpoint signaling. Predicted to act upstream of or within cell division and meiotic cell cycle. Predicted to be located in nucleus. Predicted to be part of bub1-bub3 complex and mitotic checkpoint complex. Predicted to be active in kinetochore and nucleoplasm. Orthologous to human BUB3 (BUB3 mitotic checkpoint protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (49146715..49151049, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (49193302..49197704, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of bub1-bub3 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of mitotic checkpoint complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitotic checkpoint protein BUB3

Names: BUB3 budding uninhibited by benzimidazoles 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205709.1 → NP_991272.1 mitotic checkpoint protein BUB3

See identical proteins and their annotated locations for NP_991272.1

Status: PROVISIONAL

Source sequence(s)

AY391411

UniProtKB/TrEMBL

A0A8M1PGQ9, Q6TNV6

Related

ENSDARP00000151878.1, ENSDART00000182290.1

Conserved Domains (3) summary

COG2319
Location:11 → 296

WD40; WD40 repeat [General function prediction only]

sd00039
Location:17 → 54

7WD40; WD40 repeat [structural motif]

cl02567
Location:11 → 296

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

49146715..49151049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169505.5 → XP_005169562.1 mitotic checkpoint protein BUB3 isoform X1

UniProtKB/TrEMBL

A0A8M2BHD0, U3JAH9

Related

ENSDARP00000127247.1, ENSDART00000153244.2

Conserved Domains (3) summary

COG2319
Location:23 → 308

WD40; WD40 repeat [General function prediction only]

sd00039
Location:29 → 66

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 308

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...