krt4 keratin 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: krt4provided by ZNC
Official Full Name: keratin 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-000607-83
See related: Ensembl:ENSDARG00000017624 AllianceGenome:ZFIN:ZDB-GENE-000607-83
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb59; krt8; zf-K8; wu:fa91a11; wu:fd19e09; wu:fl23c09; etID20321.6
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including digestive system; ectoderm; endocrine system; head; and integument. Human ortholog(s) of this gene implicated in several diseases, including Meesmann corneal dystrophy 2; autosomal dominant woolly hair; hypotrichosis (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT8 (keratin 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (39308498..39313038, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (39310962..39315502, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fl23c09.x1 (e-PCR)
- UniSTS:202074

AI353536 (e-PCR)
- UniSTS:206760

fe18a04.y1 (e-PCR)
- UniSTS:196271

fa91a11.x1 (e-PCR)
- UniSTS:189622

fa91a11.x1 (e-PCR)
- UniSTS:189623

fd19e09.x1 (e-PCR)
- UniSTS:204247

fa93e07.y1 (e-PCR)
- UniSTS:189681

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 4

Names: cytokeratin; keratin 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131509.2 → NP_571584.2 keratin, type II cytoskeletal 4

Status: VALIDATED

Source sequence(s)

CN508834, CR753817, DT055310, EH488376, EH999878

UniProtKB/TrEMBL

A0A8M1P5N6, F1QK60

Related

ENSDARP00000016453.6, ENSDART00000012644.7

Conserved Domains (3) summary

pfam00038
Location:113 → 424

Filament; Intermediate filament protein

pfam16208
Location:82 → 110

Keratin_2_head; Keratin type II head

cl24005
Location:304 → 399

DUF2570; Protein of unknown function (DUF2570)