lonp1 lon peptidase 1, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lonp1provided by ZNC
Official Full Name: lon peptidase 1, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4006
See related: Ensembl:ENSDARG00000102765 AllianceGenome:ZFIN:ZDB-GENE-030131-4006
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prss15; fc64d11; wu:fc64d11
Summary: Predicted to enable ATP-dependent peptidase activity and single-stranded DNA binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; mitochondrion organization; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to act upstream of or within protein catabolic process and proteolysis. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in caudal fin and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (3161164..3182763, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (3143901..3165567, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa11d10.s1 (e-PCR)
- UniSTS:202305

fj41h06.y1 (e-PCR)
- UniSTS:199321

fc64d11.x1 (e-PCR)
- UniSTS:203968

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidation-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein quality control for misfolded or incompletely synthesized proteins	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lon protease homolog, mitochondrial

Names: protease, serine, 15

XP_691712.4

EC 3.4.21.53

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

3161164..3182763 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_686620.10 → XP_691712.4 lon protease homolog, mitochondrial

UniProtKB/TrEMBL

A0A0R4IH79, A0A8N7T7A0

Related

ENSDARP00000134801.1, ENSDART00000158009.2

Conserved Domains (5) summary

smart00464
Location:131 → 228

LON; Found in ATP-dependent protease La (LON)

TIGR00763
Location:132 → 962

lon; endopeptidase La

pfam00004
Location:533 → 675

AAA; ATPase family associated with various cellular activities (AAA)

cl21455
Location:489 → 564

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl21678
Location:751 → 957

ChlI; Subunit ChlI of Mg-chelatase