ddt D-dopachrome tautomerase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddtprovided by ZNC
Official Full Name: D-dopachrome tautomeraseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-160
See related: Ensembl:ENSDARG00000044751 AllianceGenome:ZFIN:ZDB-GENE-040625-160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86714; wu:fb49f11
Summary: Predicted to enable phenylpyruvate tautomerase activity. Acts upstream of or within inner ear development and negative regulation of apoptotic process. Predicted to be active in extracellular space. Is expressed in brain; otic vesicle; pectoral fin bud; sensory system; and solid lens vesicle. Orthologous to several human genes including DDT (D-dopachrome tautomerase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (15709112..15711760)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (15613135..15615783)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D-dopachrome decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables phenylpyruvate tautomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inner ear development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: D-dopachrome decarboxylase

NP_001002147.1

EC 4.1.1.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002147.1 → NP_001002147.1 D-dopachrome decarboxylase

See identical proteins and their annotated locations for NP_001002147.1

Status: PROVISIONAL

Source sequence(s)

BC071391

UniProtKB/TrEMBL

Q6IQL4

Related

ENSDARP00000065771.4, ENSDART00000065772.5

Conserved Domains (1) summary

cl00235
Location:2 → 116

4Oxalocrotonate_Tautomerase; 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one ...