hgd homogentisate 1,2-dioxygenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hgdprovided by ZNC
Official Full Name: homogentisate 1,2-dioxygenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020802-5
See related: Ensembl:ENSDARG00000058005 AllianceGenome:ZFIN:ZDB-GENE-020802-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hgo
Summary: Predicted to enable homogentisate 1,2-dioxygenase activity. Predicted to be involved in L-phenylalanine catabolic process. Predicted to act upstream of or within tyrosine metabolic process. Is expressed in digestive system; eye; fin; median fin fold; and pectoral fin bud. Human ortholog(s) of this gene implicated in alkaptonuria. Orthologous to human HGD (homogentisate 1,2-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (23959552..23971046)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (23814378..23825872)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables homogentisate 1,2-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables homogentisate 1,2-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tyrosine metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homogentisate 1,2-dioxygenase

NP_694498.2

EC 1.13.11.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.