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    gpd1b glycerol-3-phosphate dehydrogenase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 325181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpd1bprovided by ZNC
    Official Full Name
    glycerol-3-phosphate dehydrogenase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3906
    See related
    Ensembl:ENSDARG00000043180 AllianceGenome:ZFIN:ZDB-GENE-030131-3906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Gpd1; gpd1h; gpd1l; zgc:66051; zgc:85742; wu:fc58b05
    Summary
    Predicted to enable NAD binding activity; glycerol-3-phosphate dehydrogenase (NAD+) activity; and protein homodimerization activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including intermediate cell mass of mesoderm; neural plate; notochord; ventral mesoderm; and yolk syncytial layer. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gpd1b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (6996046..7006925, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (6966200..6977079, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch73-213k20.5 Neighboring gene CD48 antigen-like Neighboring gene fibroblast growth factor receptor 1b, like Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D1 Neighboring gene uncharacterized LOC100535550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414
    2. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. Howarth DL, et al. PLoS Genet, 2014. PMID 24874946, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate dehydrogenase 1b
    Names
    glycerol-3-phosphate dehydrogenase 1 (soluble), like
    glycerol-3-phosphate dehydrogenase 1h
    NP_956000.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199706.1 → NP_956000.1  glycerol-3-phosphate dehydrogenase 1b

      See identical proteins and their annotated locations for NP_956000.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055382
      UniProtKB/TrEMBL
      Q7T1E0
      Related
      ENSDARP00000114396.1, ENSDART00000133143.2
      Conserved Domains (3) summary
      TIGR03376
      Location:5 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:5 → 171
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:197 → 337
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      6996046..7006925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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